Symlin (pramlintide) at 360 mcg twice a day caused more weight loss than lower doses

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Thursday, September 11, 2008 2:31 pm Email this article
When Symlin (pramlintide) was injected twice a day instead of three times per day, 360 mcg caused more weight loss than 240 mcg or 120 mcg according to a new study.

When given twice a day, injections were given before breakfast and dinner. The lunch dose was skipped.

"In contrast to three-times-daily dosing regimens, a clear dose-response relationship was evident among twice-daily regimens, whereby 120 [mcg twice a day] was suboptimal and 360 [mcg twice a day] elicited weight loss of a magnitude similar to the three-times-daily regimens," the authors of a new study noted.

"Thus, at higher doses, twice-daily dosing appears to be a feasible pramlintide regimen for weight loss."

Comment: In other words, 120 mcg three times per day causes as much weight loss as higher doses, however, if a patient only prefers to give themselves injections twice a day instead of three times per day, then giving 360 mcg twice a day also works. REFERENCE

Smith S, Aronne L, Burns C, Kesty N, Halseth A, Weyer C. Sustained weight loss following 12-month pramlintide treatment as an adjunct to lifestyle intervention in obesity. Diabetes Care. 2008 Sep, 31(9):1816-23.

AUTHOR’S CONTACT INFORMATION

Christian Weyer, MD
Amylin Pharmaceuticals
San Diego, California USA
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Steve R. Smith, MD
Pennington Biomedical Research Center
Louisiana State University
Baton Rouge, Louisiana USA
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• Symlin (pramlintide)