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    Symlin (pramlintide) (120 mcg three times per day) plus 10 mg Meridia caused weight loss of 24.9 lbs


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    Friday, September 12, 2008 1:08 pm Email this article
    People injecting 120 mcg of the diabetes drug Symlin (pramlintide) three times per day plus dietary counseling plus 10 mg of Meridia (sibutramine) in the morning lost an average of 24.9 pounds in six months compared to 4.6 pounds for those given a placebo (injections plus pills) according to a study by Amy Halseth, MD from Amylin Pharmaceuticals, San Diego, California presented at the European Association for the Study of Diabetes 2008. Weight Loss as Percent of Body Weight

    Weight loss as percent of body weight: 11% vs 2%

    The weight loss was roughly 11 percent of body weight with Symlin (pramlintide) plus Meridia (sibutramine) versus 2 percent with placebo.

     

    5% Weight Loss

    78% of patients lost 5% of their body weight

    More than three-fourths (78 percent) of patients given Symlin (pramlintide) plus Meridia (sibutramine) lost 5 percent of their body weight compared to 28 percent given a placebo.

     

    10% Weight Loss

    49% of patients lost 10% of their body weight

    Nearly half (49 percent) of patients given Symlin (pramlintide) plus Meridia (sibutramine) lost 10 percent of their body weight compared to 3 percent given a placebo.

     

    Subjects

    Subjects: 244 overweight or obese patients

    The study involved 244 overweight or obese patients.

    REFERENCE

    Halseth A. Enhanced weight loss following co-administration of pramlintide with sibutramine or phentermine in obese subjects. European Association for the Study of Diabetes 2008. 2008 Sep 9, Abstract 798, as reported by Stein, J. Adding Sibutramine or Phentermine to Pramlintide Increases Weight Loss in Overweight or Obese Patients: Presented at EASD. DocGuide.com, 2008 Sep 9, http://www.docguide.com/news/content.nsf/news/852571020057CCF6852574C1000D055F

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