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Symlin (pramlintide) (120 mcg three times per day) plus phentermine caused weight loss of 24.9 lbs
Friday, September 12, 2008 1:02 pm Email this article
People injecting 120 mcg of the diabetes drug Symlin (pramlintide) three times per day plus dietary counseling plus 37.5 mg of phentermine in the morning lost an average of 24.9 pounds in six months compared to 4.6 pounds for those given a placebo (injections plus pills) according to a study by Amy Halseth, MD from Amylin Pharmaceuticals, San Diego, California presented at the European Association for the Study of Diabetes 2008. Weight Loss as Percent of Body Weight
Weight loss as percent of body weight: 11% vs 2%
The weight loss was roughly 11 percent of body weight with Symlin (pramlintide) plus phentermine versus 2 percent with placebo.
5% Weight Loss
78% of patients lost 5% of their body weight
More than three-fourths (82 percent) of patients given Symlin (pramlintide) plus phentermine lost 5 percent of their body weight compared to 28 percent given a placebo.
10% Weight Loss
56% of patients lost 10% of their body weight
More than half (56 percent) of patients given Symlin (pramlintide) plus phentermine lost 10 percent of their body weight compared to 3 percent given a placebo.
Subjects: 244 overweight or obese patients
The study involved 244 overweight or obese patients.
Halseth A. Enhanced weight loss following co-administration of pramlintide with sibutramine or phentermine in obese subjects. European Association for the Study of Diabetes 2008. 2008 Sep 9, Abstract 798, as reported by Stein, J. Adding Sibutramine or Phentermine to Pramlintide Increases Weight Loss in Overweight or Obese Patients: Presented at EASD. DocGuide.com, 2008 Sep 9, http://www.docguide.com/news/content.nsf/news/852571020057CCF6852574C1000D055F
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