Symlin (pramlintide) (120 mcg three times per day) plus phentermine caused weight loss of 24.9 lbs

Posted by .(JavaScript must be enabled to view this email address)
Friday, September 12, 2008 1:02 pm Email this article
People injecting 120 mcg of the diabetes drug Symlin (pramlintide) three times per day plus dietary counseling plus 37.5 mg of phentermine in the morning lost an average of 24.9 pounds in six months compared to 4.6 pounds for those given a placebo (injections plus pills) according to a study by Amy Halseth, MD from Amylin Pharmaceuticals, San Diego, California presented at the European Association for the Study of Diabetes 2008. Weight Loss as Percent of Body Weight

Weight loss as percent of body weight: 11% vs 2%

The weight loss was roughly 11 percent of body weight with Symlin (pramlintide) plus phentermine versus 2 percent with placebo.

 

5% Weight Loss

78% of patients lost 5% of their body weight

More than three-fourths (82 percent) of patients given Symlin (pramlintide) plus phentermine lost 5 percent of their body weight compared to 28 percent given a placebo.

 

10% Weight Loss

56% of patients lost 10% of their body weight

More than half (56 percent) of patients given Symlin (pramlintide) plus phentermine lost 10 percent of their body weight compared to 3 percent given a placebo.

 

Subjects

Subjects: 244 overweight or obese patients

The study involved 244 overweight or obese patients.

REFERENCE

Halseth A. Enhanced weight loss following co-administration of pramlintide with sibutramine or phentermine in obese subjects. European Association for the Study of Diabetes 2008. 2008 Sep 9, Abstract 798, as reported by Stein, J. Adding Sibutramine or Phentermine to Pramlintide Increases Weight Loss in Overweight or Obese Patients: Presented at EASD. DocGuide.com, 2008 Sep 9, http://www.docguide.com/news/content.nsf/news/852571020057CCF6852574C1000D055F

Articles on the same subject can be found here:

• Phentermine

• Symlin (pramlintide)