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    Symlin (pramlintide) (120 mcg three times per day) plus phentermine caused weight loss of 24.9 lbs

    Posted by .(JavaScript must be enabled to view this email address)
    Friday, September 12, 2008 12:20 pm Email this article
    One serious event occurred in a patient injecting 120 mcg of the diabetes drug Symlin (pramlintide) three times per day plus 37.5 mg of phentermine according to a study by Amy Halseth, MD from Amylin Pharmaceuticals, San Diego, California presented at the European Association for the Study of Diabetes 2008.

    They did not say what the event was. Two Serious Events with Placebo

    Two serious events in patient given placebo

    Two serious evens occurred in patients given placebo (injections and pills).


    Not Related to the Medications?

    Researchers judged the events not related to the medications

    None of these events was judged to be related to the study medication.



    Comment: NONSENSE!

    This is NONSENSE!

    This is what they ALWAYS say!

    Although I would have to know what the specific adverse event was to know for sure, but in all likelihood, this is nonsense.

    I would guess that the serious adverse effect—heart attack, stroke or whatever—was caused by the drugs.

    I believe that this is due to the legal environment in the U.S.

    If they admitted that the serious adverse event might have been caused by the drugs, lawyers would jump all over this, and file massive lawsuits any time this serious adverse event occurred in the future and the drug companies would have no defense.

    The lawyers would argue, “They’ve already admitted the drug(s) can cause this!”

    And the case would be over.

    Therefore, they will ALWAYS deny it!



    Comment: They MUST deny it!

    They MUST deny it!

    It is unfortunate it is this way, but the drug companies are just protecting themselves from



    Comment: Same denial happened in Meridia study

    The same thing happened in a study with Merida (sibutramine) before it was approved for sale in the U.S.

    A man given Merida (sibutramine) had a stroke.

    The study, which was coauthored by one of the most famous obesity researchers, said something like, “We don’t think the stroke had anything to do with Merida (sibutramine).”

    And that is all they said.

    They did not explain it.

    Of course it had something to do with Merida (sibutramine) based on the way the drug works.

    And since then, several strokes have been reported in patients taking Merida (sibutramine).

    But, again, they HAD TO deny it to protect themselves from lawyers who would try to sue them out of business.


    Halseth A. Enhanced weight loss following co-administration of pramlintide with sibutramine or phentermine in obese subjects. European Association for the Study of Diabetes 2008. 2008 Sep 9, Abstract 798, as reported by Stein, J. Adding Sibutramine or Phentermine to Pramlintide Increases Weight Loss in Overweight or Obese Patients: Presented at EASD. DocGuide.com, 2008 Sep 9, http://www.docguide.com/news/content.nsf/news/852571020057CCF6852574C1000D055F

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