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    Symlin (pramlintide) (120 mcg three times per day) plus phentermine: One serious adverse event


    Posted by .(JavaScript must be enabled to view this email address)
    Friday, September 12, 2008 12:20 pm Email this article
    One serious event occurred in a patient injecting 120 mcg of the diabetes drug Symlin (pramlintide) three times per day plus 37.5 mg of phentermine according to a study by Amy Halseth, MD from Amylin Pharmaceuticals, San Diego, California presented at the European Association for the Study of Diabetes 2008.

    They did not say what the adverse event was. Serious adverse events are things like a heart attack or stroke. Two Serious Events with Placebo

    Two serious events in patient given placebo

    Two serious evens occurred in patients given placebo (injections and pills).

     

    Not Related to the Medications?

    Researchers judged the events not related to the medications

    None of these events was judged to be related to the study medication.

     

    Comment #1

    Comment: NONSENSE!

    This is NONSENSE!

    This is what they ALWAYS say!

    Although I would have to know what the specific adverse event was to know for sure, but in all likelihood, this is nonsense.

    I would guess that the serious adverse effect—heart attack, stroke or whatever—was caused by the drugs.

     

    Comment #2

    Comment #3: They MUST deny it due to the legal system

    I believe that the reason that they always deny that a serious adverse event is due to a drug is due to the legal environment in the U.S.

    If they admitted that the serious adverse event might have been caused by the drugs, lawyers would jump all over this, and file massive lawsuits any time this serious adverse event occurred in the future and the drug companies would have no defense.

    The lawyers would argue, “They’ve already admitted the drug(s) can cause this!”

    And the case would be over.

    Therefore, they will ALWAYS deny it!

    They MUST deny it!

    It is unfortunate it is this way, but the drug companies are just protecting themselves from lawyers who would sue them out of business.

     

    Comment #3

    Comment #3: Same denial happened in Meridia study

    The same thing happened in a study with Merida (sibutramine) before it was approved for sale in the U.S.

    A man given Merida (sibutramine) had a stroke.

    The study, which was coauthored by one of the most famous obesity researchers, said something like, “We don’t think the stroke had anything to do with Merida (sibutramine).”

    And that is all they said.

    They did not explain it.

    This was nonsense.

    In all likelihood the stroke was caused by Merida (sibutramine) based on the way the drug works.

    Since then, several strokes have been reported in patients taking Merida (sibutramine).

    But, again, they HAD TO deny it to protect themselves from lawyers who would try to sue them out of business.

     

    Comment #4

    Comment #4: Same denial by Tobacco executives

    Several years ago the presidents of several tobacco companies gave the same denial for the same reason in front of the U.S. congress.

    Every one of them got up and said, “I do not believe that nicotine is addictive.”

    Of course nicotine is addictive.

    It’s very addictive and everyone knows it.

    But they HAD TO deny it or else the lawyers would have sued them out of business.

    If they had admitted it, the lawyers would have filed massive lawsuits for everyone who is addicted to cigarettes and said, “They admitted that nicotine is addictive!”

    So they HAD TO deny it.

     

    Comment #5

    Comment #5: Just be aware that serious adverse events are possible with ANY drug

    The takeaway message is just to be aware that serious adverse events are possible with ANY drug.

    Be careful, and if something does not feel right, see a doctor immediately.

    REFERENCE

    Halseth A. Enhanced weight loss following co-administration of pramlintide with sibutramine or phentermine in obese subjects. European Association for the Study of Diabetes 2008. 2008 Sep 9, Abstract 798, as reported by Stein, J. Adding Sibutramine or Phentermine to Pramlintide Increases Weight Loss in Overweight or Obese Patients: Presented at EASD. DocGuide.com, 2008 Sep 9, http://www.docguide.com/news/content.nsf/news/852571020057CCF6852574C1000D055F

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