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Whole body vibration lowered body weight of rats by 6.8% without any change in food intake
Monday, September 15, 2008 2:09 pm Email this article
Female rats that were given whole body vibration 30 minutes per day, 5 days per week for three months, weighed 6.8 percent less than other rats according to a new study from Oregon State University in Corvallis, Oregon, USA. Vibration
Vibration given 5 minutes at a time, then a one minute break, repeated 6 times
Vibration was done 5 minutes at a time, then a one minute break.
This was repeated 6 times for a total of 30 minutes per day.
This was done 5 days per week.
Body fat two percentage points lower
Percent body fat was 2 percentage points lower in the vibrated rats—10.2 percent versus 12.2 percent.
Muscle and Bone
No difference in muscle and bone
There was no difference in lean body mass, bone mineral content or bone mineral density, or insulin-like growth factor-1.
Leptin levels lower
Leptin levels were less than half in vibrated rats—1.1 versus 2.3 nanograms per millileter.
No difference in food consumption
There was no difference in food consumption between the vibrated rats and the controls—78.2 grams versus 77.5 grams per week.
Rats were 7 months old
The female rats were 7-months-old.
Rats live roughly 3 years, so 7 months old would be the equivalent of a 15-year-old human (approximately one-fifth of the way through their life.)
“These findings show that whole-body vibration reduced body fat accumulation and serum leptin without affecting whole body [bone mineral content], [bone mineral density] or lean mass,” the researchers concluded.
“However, the increase in vertebral [bone mineral content] and [bone mineral density] suggests that vibration may have resulted in local increases in bone mass and density.
“Also, whole-body vibration did not affect muscle function or food consumption.”
Comment #1: I assume the weight loss is from muscle contractions
Since there was no difference in food consumption, I assume that the weight loss occurred because of muscle contractions with the body trying to counter the effects of the vibration.
This would be kind of like trying to keep your balance.
Comment #2: Weight loss might have been due to an increase in metabolism due to elevated noradrenaline
I wish they would have measured levels of dopamine, adrenaline and noradrenaline to determine if the vibration caused an increase.
It could be that the lower body weight was simply caused by an increase in metabolism caused by elevated noradrenaline levels.
This would also explain the lower leptin levels seen in the vibrated rats.
“Catecholamines [dopamine, adrenaline and noradrenaline] inhibit leptin secretion,” as noted by Calissendorff et al (2004).
Maddalozzo GF, Iwaniec UT, Turner RT, Rosen CJ, Widrick JJ. Whole-body vibration slows the acquisition of fat in mature female rats. Int J Obes (Lond). 2008 Sep 9, 32(9):1348–54.
AUTHOR’S CONTACT INFORMATION
Dr. Gianni F. Maddalozzo
Bone Research Laboratory
Department of Nutrition and Exercise Sciences
Oregon State University
Corvallis, OR 97331, USA
Calissendorff J, Brismar K, Rojdmark S. Is decreased leptin secretion after alcohol ingestion catecholamine-mediated? Alcohol Alcohol. 2004 Jul-Aug, 39(4):281-86.
AUTHOR’S CONTACT INFORMATION
Department of Endocrinology and Diabetology
117 76 Stockholm, Sweden
Articles on the same subject can be found here:
On Nov 16, 2008 at 9:32 pm Itsme wrote:
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It's possible that you're right about the muscle contractsions. I have read that it's the vibrations from load-bearing exercise that helps increase bone density, and since bone density increased here, it seems likely this is using the same mechanism to increase bone density.
It's also possible that whatever process that is triggered by the vibration that causes the bone density to increase, also triggers some of the other body changes.
On Nov 17, 2008 at 7:39 am Larry Hobbs wrote:
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Thanks for your input.
On Nov 18, 2008 at 10:14 am sal wrote:
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there's a more interesting study posted on this site that was done with humans that shows WBV doesn't do anything.
why bother studying rats and mice when studies with humans show WBV to have no appreciable impact, especially considering its inconvenience of use and expense?
On Nov 18, 2008 at 11:12 am Larry Hobbs wrote:
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On May 09, 2009 at 11:38 am ADELAIDE wrote:
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Naltrexone and its Multiple Uses
Naltrexone is not a drug that is new on the scene. This substance was first approved in 1994 by the FDA to assist alcohol abusers safely detox from alcohol. Recently however, naltrexone is being used to treat other conditions. The uses range from its original purpose- alcohol use treatment, to stopping nicotine use decreasing the possibility of kleptomania, heroin and morphine use and even for relief from symptoms of fibromyalgia.
A study conducted recently explores the use of naltrexone in preventing kleptomania. Kleptomania is defined as an individual?s incessant need to steal. It?s often not an issue of what is getting stolen, as kleptomania really has to do with the thrill or excitement an individual feels when stealing. Examples of famous persons who have exhibited kleptomaniac tendencies includes actress Winona Ryder. The study was conducted at the University of Minnesota and included 25 participants, 23 of which completed the study. The study lasted for two months and participants were assessed every two months through self report. Variables measured included anxiety, psychosocial functioning, depression as well as a scale specifically for kleptomania. After eight weeks of treatment for those in the experimental group (those receiving medication) there was a significant decline in the desire to shoplift and actually stealing as well as a decrease in scores of kleptomaniac scales.
Researchers attribute the affect of the drug to the fact that it blocks pleasure centers of the brain which means when an individual steals, he or she will not feel the high associated with stealing. Though other therapy should be incorporated into kleptomania treatment, this was an important finding.
Another study examined the use of naltrexone for alcohol abusers who also smoked. The same principles are in play here, as again, naltrexone?s purpose is to block pleasure receptors in the brain that are activated which substances are used. We already know that naltrexone works to help in alcohol abuse. Many alcoholics, or heavy social drinkers, concurrently heavily smoke. Often, the smoking is triggered by alcohol use. Both of these substances put the user at significant risk of damaging their health permanently. An individual who smokes and drinks alcohol is at a higher risk of dying prematurely from tobacco related complications than alcohol related complications. Since naltrexone is well tolerated, this finding could really assist in long term abstinence to two very serious substance abuse problems.
In terms of heroin abuse, naltrexone use has reduced detoxification from heroin from two weeks, to one day. With further study, heroin detoxification was even reduced to just four to six hours. The implications of this are many. First, it makes it easier for the user, which means he or she will be more likely to try to try to detox. Secondly, is the cost of the detoxification is greatly reduced if an individual only needs to be inpatient for one to two days. It is suggested that uses of naltrexone is best in highly motivated populations as stopping the drug does not have any negative side effects and may result in reduced long term abstinence for those having difficulty abstaining. However, if naltrexone is used for detoxification in conjunction with supportive therapy the results should be long lasting.
Low Dose Naltrexone?
In the case of smoking cessation, naltrexone is prescribed at a dose of 50mg daily. What happens if the dose is reduced to only 5 mg? Well, in the case of a substance abuser, chances are nothing would happen. The naltrexone may not procure any notable change. However, as a researcher at Stanford University recently noted in a study published in Pain Medicine, low dose naltrexone may be useful in the treatment of fibromyalgia, as well as other autoimmune disease including Multiple Sclerosis and Crohn?s disease.
Firbromyalgia is defined as chronic pain in the muscles of the body. These individuals are chronically fatigued and have difficulty sleeping. The discomfort from fibromyalgia which also includes headaches, stomach problems among other things, often prevent these individuals from living full and meaningful lives. The number of people suffering from the disease in the U.S. reaches the millions. Though there are three FDA approved medications for the disorder, they do not work for everyone.
The study was small, conducted with ten women participants. The study participants received the medication for a total of ten weeks. Two weeks they received a placebo pill and eight weeks of low dose naltrexone (LDN). They reported their symptoms on a hand held computer. In six of the ten participants, the LDN given was significantly more effective than placebo at reducing symptoms. Sleep problems, GI symptoms and headaches were also reduced. More research needs to be done, and Stanford is currently organizing to run another larger study on the use of LDN for autoimmune illness. At this point, all the possible uses of naltrexone are not known, however, the studies already conducted and those underway give a sense of hope for assistance in other areas.
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