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  • Leptin deficiency alters sleep in mice, lowers metabolism during sleep

    Posted by .(JavaScript must be enabled to view this email address)
    Friday, October 10, 2008 7:04 am Email this article
    Leptin deficiency alters sleep according to research from researchers at Northwestern University in Evanston, Illinois, USA.

    Leptin-deficient mice (ob/ob mice) had more arousals during sleep, and more frequent, but shorter-lasting sleep bouts, and also showed lower body temperature, in other words, lower metabolism during sleep.

    They also did not recover as well from sleep deprivation when they were allowed to sleep. REFERENCES

    Laposky A, Bradley M, Williams D, Bass J, Turek F. Sleep-wake regulation is altered in leptin resistant (db/db) genetically obese and diabetic mice. Am J Physiol Regul Integr Comp Physiol. 2008 Oct 8.

    Laposky A, Shelton J, Bass J, Dugovic C, Perrino N, Turek F. Altered sleep regulation in leptin-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2006 Apr, 290(4):R894-903.


    Aaron D. Laposky
    Northwestern University
    Department of Neurobiology and Physiology
    Center for Sleep and Circadian Biology
    2205 Tech Drive
    Hogan 2-160
    Evanston, IL 60208-3520 USA
    Phone: (847) 491-2072
    FAX: (847) 467-4065
    .(JavaScript must be enabled to view this email address)


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