Leptin deficiency alters sleep in mice, lowers metabolism during sleep

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Friday, October 10, 2008 7:04 am Email this article
Leptin deficiency alters sleep according to research from researchers at Northwestern University in Evanston, Illinois, USA.

Leptin-deficient mice (ob/ob mice) had more arousals during sleep, and more frequent, but shorter-lasting sleep bouts, and also showed lower body temperature, in other words, lower metabolism during sleep.

They also did not recover as well from sleep deprivation when they were allowed to sleep. REFERENCES

Laposky A, Bradley M, Williams D, Bass J, Turek F. Sleep-wake regulation is altered in leptin resistant (db/db) genetically obese and diabetic mice. Am J Physiol Regul Integr Comp Physiol. 2008 Oct 8.

Laposky A, Shelton J, Bass J, Dugovic C, Perrino N, Turek F. Altered sleep regulation in leptin-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2006 Apr, 290(4):R894-903.

AUTHOR’S CORRESPONDENCE

Aaron D. Laposky
Northwestern University
Department of Neurobiology and Physiology
Center for Sleep and Circadian Biology
2205 Tech Drive
Hogan 2-160
Evanston, IL 60208-3520 USA
Phone: (847) 491-2072
FAX: (847) 467-4065
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