Two months after stopping 1 mg of Tesofensine, patients had gained 3.8% vs 0.5% with placebo

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Wednesday, October 29, 2008 9:04 am Email this article
Two months after the drug was stopped, those who had been given 1 mg of Tesofensine per day had regained 3.8 percent of body weight versus 0.5 percent for those given a placebo. Drug’s Mechanism of Action

Inhibits reuptake of serotonin, noradrenaline and dopamine

Tesofensine works by inhibiting reuptake of serotonin, noradrenaline and dopamine.

 

Subjects

Subjects: 203 obese patients

The study involved 203 obese patients with a body mass index (BMI) of 30-40.

The average starting weight of those in the 0.25 mg group was 225.9 pounds versus 229.5 pounds for those in the placebo group.

 

Comment

Comment: This is a very powerful drug

This is a powerful drug simply from the fact that the doses used are so small.

It will be interesting to see the results of longer studies to see if the weight loss can be maintained after six months.

Studies with serotonin reuptake inhibitors like Prozac (fluoxetine) show weight loss for the first six months, but after a year or so, there is no significant weight loss from before they were given the drug.

REFERENCE

Astrup A, Madsbad S, Breum L, Jensen T, Kroustrup J, Larsen T. Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: A randomised, double-blind, placebo-controlled trial. Lancet. 2008 Oct 22, published on-line.

AUTHOR’S CONTACT INFORMATION

Prof Arne Astrup
The Department of Human Nutrition
Faculty of Life Sciences
University of Copenhagen
Rolighedsvej 30
DK-1958 Frederiksberg, Denmark
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Articles on the same subject can be found here:

• Tesofensine