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Tesofensine side effects: Constipation in 16% given 1 mg vs 2% with 0.5 mg vs 10% with 0.25 mg
Wednesday, October 29, 2008 8:41 am Email this article
Among patients given Tesofensine, constipation was reported by 16 percent given 1 mg per day versus 2 percent given 0.5 mg versus 10 percent given 0.25 mg versus 8 percent given a placebo. Drug’s Mechanism of Action
Inhibits reuptake of serotonin, noradrenaline and dopamine
Tesofensine works by inhibiting reuptake of serotonin, noradrenaline and dopamine.
Subjects: 203 obese patients
The study involved 203 obese patients with a body mass index (BMI) of 30-40.
The average starting weight of those in the 0.25 mg group was 225.9 pounds versus 229.5 pounds for those in the placebo group.
Comment: This is a very powerful drug
This is a powerful drug simply from the fact that the doses used are so small.
It will be interesting to see the results of longer studies to see if the weight loss can be maintained after six months.
Studies with serotonin reuptake inhibitors like Prozac (fluoxetine) show weight loss for the first six months, but after a year or so, there is no significant weight loss from before they were given the drug.
Astrup A, Madsbad S, Breum L, Jensen T, Kroustrup J, Larsen T. Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: A randomised, double-blind, placebo-controlled trial. Lancet. 2008 Oct 22, published on-line.
AUTHOR’S CONTACT INFORMATION
Prof Arne Astrup
The Department of Human Nutrition
Faculty of Life Sciences
University of Copenhagen
DK-1958 Frederiksberg, Denmark
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