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  • Contrave plus diet, exercise causes weight loss of 11.5% vs 7.3% in those completing one year study

    Posted by .(JavaScript must be enabled to view this email address)
    Thursday, August 19, 2010 10:10 am Email this article
    Among participants who completed the entire one-year (56 week) study, those given Contrave (bupropion SR (Wellbutrin) plus naltrexone SR) combined with an intensive program of diet, exercise, and behavior modification therapy to lost an average of 11.5% of body weight compared to 7.3% for those given a placebo.

    The average weight loss in the drug group was 26 lbs, reducing their body weight from 224 lbs to 198 lbs, a 11.5% weight loss, compared an average weight loss in the placebo group was 16 lbs, reducing their body weight from 220 lbs to 204 lbs, a 7.3% weight loss.

    Note: In order to calculate weight loss in pounds, I made the assumption that the average body weight of those who completed the study was the same as the entire group.

    For additional information on this study, see here.


    Wadden TA, Foreyt J, Foster G, Hill J, Klein S, O’Neil PM, Perri M, Pi-Sunyer FX, Rock C, Erickson J, Maier H, Kim D, Dunayevich E. Weight loss with naltrexone sr/bupropion sr combination therapy as an adjunct to behavior modification: The cor-bmod trial. Obesity (Silver Spring). 2010 Jun 17, Epub ahead of print.


    Thomas A. Wadden
    Department of Psychiatry
    Center for Weight and Eating Disorders
    University of Pennsylvania School of Medicine
    Philadelphia, Pennsylvania, USA
    .(JavaScript must be enabled to view this email address)

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