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  • A caffeine-free EGCG supplement does NOT increase resting metabolism


    Posted by .(JavaScript must be enabled to view this email address)
    Monday, August 23, 2010 12:50 pm Email this article
    A caffeine-free supplement of EGCG (Epigallocatechin-3-gallate) does NOT increase resting metabolism, nor does it increase thermogenesis following a meal according to a new study from researchers at Colorado State University in Fort Collins, Colorado, USA.

    These results were the opposite of what these researchers expected.

    "Contrary to our hypothesis, we found no stimulatory effect of short-term administration on either [ resting metabolic rate ] or [the thermic effect of food ], the researchers concluded. Resting Metabolism

    Resting metabolism with and without EGCG: 1610 calories vs 1665 calories

    Resting metabolism when given the caffeine-free EGCG supplement was 1610 calories per day vs 1665 when given a placebo.

     

    No Effect on the Thermic Effect of Food

    No Effect on the Thermic Effect of Food with or without EGCG

    They also found that the caffeine-free EGCG supplement had no effect on the thermic effect of food, that is, the amount of thermogenesis following a meal.

     

    Dose

    Dose: One capsule containing 135 mg of EGCG with each meal

    Subjects were given one capsule containing 135 mg of EGCG with each meal for a total of 3 capsules per day.

    Subjects took a total of 7 capsules over two days, the last capsule was taken two hours prior to visiting the laboratory.

    On a separate occasion, capsules containing a placebo were given.

     

    Subjects

    Subjects: 9 males, 7 females

    The study involved 16 adults (9 males, 7 females) with an average age of 25 years, and normal body weight with a body mass index (BMI) of 24.6.

    REFERENCE

    Lonac M, Richards J, Schweder M, Johnson T, Bell C. Influence of short-term consumption of the caffeine-free, epigallocatechin-3-gallate supplement, Teavigo, on resting metabolism and the thermic effect of feeding. Obesity (Silver Spring). 2010 Aug 19, Epub ahead of print.

    AUTHOR’S CONTACT INFORMATION

    Christopher Bell
    Department of Health and Exercise Science
    Colorado State University
    Fort Collins, Colorado, USA
    .(JavaScript must be enabled to view this email address)

    ————

     

    In 1999, Abdul Dulloo, MD, PhD Told Me Caffeine Needed to Be Combined with EGCG

    Note: In 1999 I interviewed obesity researcher, Abdul Dulloo, M.D., Ph.D. from the Institute of Physiology at the University of Fribourg in Fribourg, Switzerland.

    He told me that the interaction of caffeine and the catechins in tea (the main one being EGCG) seemed to be responsible for the increase in thermogenesis seen with green tea.

    In other words, caffeine is an important part of the equation.

    A number of years ago, the Life Extension Foundation released a caffeine-free green tea extract for weight loss. I thought this was a mistake and it would not work because of the necessity of caffeine to be combined with EGCG to work based on the research and based on this interview.

    The interview with Dr. Dulloo is posted here.

    ————

    Here is part of the interview where he talked about the importance of this interaction.

    Hobbs: How does green tea extract increase thermogenesis?

    Dulloo: We believe that it is the result of an interaction between the two main ingredients in green tea—the catechins and the caffeine—with the noradrenaline release by the sympathetic nervous system.

    The catechins in green tea inhibit an enzyme called catechol O-methyltranferase also known as COMT which degrades noradrenaline.

    Whereas caffeine inhibits the enzyme system phosphodiesterase which degrades the levels of cAMP which is responsible for thermogenesis.

    Thus the catechins and caffeine, by inhibiting COMT and phosphodiesterase, respectively, may increase the levels of noradrenaline, potentiate its effect, and prolong the life of cAMP in the cell which results in a more sustained effect of thermogenesis.

    Hobbs: Is green tea more effective than caffeine at stimulating thermogenesis?

    Dulloo: Yes.

     

    Ephedrine plus Green Tea vs Ephedrine plus Caffeine

    Hobbs: Is green tea more effective than caffeine at stimulating ephedrine-induced thermogenesis? [That is, ephedrine plus green tea vs ephedrine plus caffeine.]

    Dulloo: Yes, at least in vitro. In fact, under these conditions—that is under conditions of stimulated noradrenaline release such as when ephedrine is administered—the effect is even more pronounced than giving green tea alone.

    Hobbs: So it is not just the catechins or not just the caffeine, but the combination of the two?

    Dulloo: Yes, that’s correct.

    It seems to be the result of an interaction between the catechins and the caffeine with noradrenaline. In an in vitro study which will be published in the December 1999 issue of International Journal of Obesity we found that the thermogenic effect of green tea could be mimicked by a combination of epigallocatechin gallate—the most potent of the catechins found in green tea—and caffeine.

    This indicates that both catechins and caffeine are probably responsible for the increase in thermogenesis.

    The literature indicates that in humans, a single oral dose of caffeine must exceed 100 mg in order to have an effect on thermogenesis and a dose of 600 to 1000 mg per day seems to be necessary to increase 24-hour energy expenditure.

    —- End of Quote from the Interview with Dr. Dulloo—

    Articles on the same subject can be found here:


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