Risperdal (risperidone) + Mifeprex (mifepristone) causes weight gain of 5.1 lbs in one month in men

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Tuesday, August 24, 2010 10:15 am Email this article
Lean, healthy men gained an average of 5.1 lbs in one month (28 days) when given 600 mg of Mifeprex (mifepristone), also known as RU-486, in addition to 4.0 mg daily of the antipsychotic medication Risperdal (risperidone).

This was 4.2 lbs less than the 9.3 lbs gained by those given 4 mg of Risperdal (risperidone) alone.

Mifeprex (mifepristone) is the drug used to end pregnancy early. Subjects

Subjects: 30 men in Mifeprex (mifepristone) plus Risperdal (risperidone) group; another 30 men in Risperdal (risperidone) alone group

The study involved 76 lean, healthy, Indian men with a body mass index (BMI) of 18 to 23 who were between 18- and 40- years-old.

There were 30 men in the group given Mifeprex (mifepristone) plus Risperdal (risperidone).

Another 30 men were given just Risperdal (risperidone).

The men were in an in an institutional setting were food was provided ad libitum in a cafeteria-style format.

They were given three meals per day, and unlimited snacks.

 

Drug Dose

Drug dose: 0.5 mg increased to 4 mg over 8 days of Risperdal (risperidone); 600 mg of Mifeprex (mifepristone)

The men were started on 0.5 mg of Risperdal (risperidone) which was increased by 0.5 mg per day for 8 days when a dose of 4 mg was reached.

A dose of 600 mg of Mifeprex (mifepristone) was used.

REFERENCE

Gross C, Blasey C, Roe R, Belanoff J. Mifepristone reduces weight gain and improves metabolic abnormalities associated with risperidone treatment in normal men. Obesity (Silver Spring). 2010 Mar 25, Epub ahead of print.

AUTHOR’S CONTACT INFORMATION

Christine Blasey
Corcept Therapeutics Incorporated
Menlo Park, California, USA
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Articles on the same subject can be found here:

• Mifeprex (mifepristone)

• Risperdal (risperidone)