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    Dopamine agonists caused weight loss of 4-11 lbs in heavy men with prolactinoma


    Posted by .(JavaScript must be enabled to view this email address)
    Monday, August 30, 2010 11:30 am Email this article
    Giving the dopamine agonist cabergoline (Dostinex, Cabaser) or bromocriptine (Parlodel) to heavy men with prolactinoma -- a noncancerous pituitary tumor that produces the hormone prolactin and causes prolactin levels to be be greatly elevated -- appears to cause weight loss.

    Weight loss seems to occur in heavy men only, whereas lean men gained weight.

    One woman gained 33 lbs, however, in the other 16 women, there did not appear to be much of a weight change after 6 months.

    This is based on a very small sample size -- only 3 heavy men and 2 lean men -- so these results should be viewed as very preliminary.

    By approximating body weight from a chart in the paper, here are the weight changes in the 5 men.
    Drug Doses

    Drug doses not specified

    Unfortunately, they did not give the doses they used.

    They also noted that most people were given cabergoline (Dostinex, Cabaser), and only a few were given bromocriptine (Parlodel).

    Unfortunately, they did not specify which subjects got which drug.

    REFERENCE

    Dos Santos Silva CM, Barbosa FR, Lima G, Warszawski L, Fontes R, Domingues R, Gadelha M. Bmi and metabolic profile in patients with prolactinoma before and after treatment with dopamine agonists. Obesity (Silver Spring). 2010 Jun 17, Epub ahead of print.

    AUTHOR’S CONTACT INFORMATION

    Cintia M. dos Santos Silva
    Division of Endocrinology
    Hospital Universitario Clementino Fraga Filho
    Universidade Federal do Rio de Janeiro
    Rio de Janeiro, Brazil
    .(JavaScript must be enabled to view this email address)

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