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Elavil (amitriptyline) caused average weight gain of 5.3 lbs in six months
Monday, April 04, 2011 3:12 pm Email this article
Elavil (amitriptyline) caused average weight gain of 5.3 lbs in six months in patients given the drug for as a preventative against migraine headaches according to a recent study. Subjects
Subjects: 331 adults, mostly women, with 3-12 migraines per month
The study involved 331 subjects (172 topiramate, 159 amitriptyline) who had 3 to 12 migraines per month.
Eighty-five percent 85% female, and 85% were white.
The average age was 39-years-old.
Their average starting weight was 169 lbs.
Dose: 25 mg per day increased to 100 mg per day
The dose used was 25 mg per day of either topiramate (Topamax) or amitriptyline (Elavil), “subsequently titrated to a maximum of 100 mg/d (or the maximum tolerated dose).”
Dodick D, Freitag F, Banks J, Saper J, Xiang J, Rupnow M, Biondi D, Greenberg S, Hulihan J. Topiramate versus amitriptyline in migraine prevention: A 26-week, multicenter, randomized, double-blind, double-dummy, parallel-group noninferiority trial in adult migraineurs. Clin Ther. 2009 Mar, 31(3):542-59.
AUTHOR’S CONTACT INFORMATION
David W. Dodick, MD
Department of Neurology
Mayo Clinic Hospital
5777 E. Mayo Boulevard
Phoenix, AZ 85054 USA
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