Depression-related events more common in those given 15 mg phentermine + 92 mg Topamax: 7.3% vs 3.8%

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Tuesday, April 26, 2011 2:33 pm Email this article
"Depression-related adverse events (excluding sleep disorders)" occurred in 7.3 percent of patients given 15 mg of phentermine plus 92 mg of Topamax (topiramate) versus 3.8 percent in those given 7.5 mg of phentermine plus 46 mg of Topamax (topiramate) versus 3.8 percent in those given a placeboaccording to a new study from Duke University in Durham, North Carolina, USA.

It took an average of approximately one-month for these symptoms to occur. Subjects

Subjects: 2487 overweight and obese patients

The study wad done at 93 centers in the US and involved 2487 overweight and obese patients who were 18- to 70-years-old, with an average age of 51.

Seventy percent (70%) of subjects were women.

• 994 were assigned to placebo
• 498 were given 7.5 mg of phentermine plus 46 mg of topiramate (Topamax)
• 995 were given 15 mg of phentermine plus 92 mg of topiramate (Topamax)

 

Body Weight

Average body weight: 226 lbs; BMI 36-37

The average body weight of the subjects was 226 pounds.

The average body mass index (BMI) was 36-37.

 

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REFERENCE

Gadde K, Allison D, Ryan D, Peterson C, Troupin B, Schwiers M, Day W. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (conquer): A randomised, placebo-controlled, phase 3 trial. Lancet. 2011 Apr 16, 377(9774):1341-52.

AUTHOR’S CONTACT INFORMATION

Dr Kishore M Gadde
Obesity Clinical Trials Programme
Box 3292
Duke University Medical Center
Durham, NC 27710, USA
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