Attention problems more common in those given 15 mg phentermine + 92 mg Topamax: 3.5% vs 0.7%

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Tuesday, April 26, 2011 2:04 pm Email this article
"Anxiety-related adverse events (including irritability)" occurred in 3.5 percent of patients given 15 mg of phentermine plus 92 mg of Topamax (topiramate) versus 2 percent in those given 7.5 mg of phentermine plus 46 mg of Topamax (topiramate) versus 0.7 percent in those given a placeboaccording to a new study from Duke University in Durham, North Carolina, USA. Subjects

Subjects: 2487 overweight and obese patients

The study wad done at 93 centers in the US and involved 2487 overweight and obese patients who were 18- to 70-years-old, with an average age of 51.

Seventy percent (70%) of subjects were women.

• 994 were assigned to placebo
• 498 were given 7.5 mg of phentermine plus 46 mg of topiramate (Topamax)
• 995 were given 15 mg of phentermine plus 92 mg of topiramate (Topamax)

 

Body Weight

Average body weight: 226 lbs; BMI 36-37

The average body weight of the subjects was 226 pounds.

The average body mass index (BMI) was 36-37.

 

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REFERENCE

Gadde K, Allison D, Ryan D, Peterson C, Troupin B, Schwiers M, Day W. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (conquer): A randomised, placebo-controlled, phase 3 trial. Lancet. 2011 Apr 16, 377(9774):1341-52.

AUTHOR’S CONTACT INFORMATION

Dr Kishore M Gadde
Obesity Clinical Trials Programme
Box 3292
Duke University Medical Center
Durham, NC 27710, USA
.(JavaScript must be enabled to view this email address)

 

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