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Hypoglycemia increases risk of cancer death by 2.3-fold over 8 years in patients with CAD
Tuesday, June 28, 2011 12:38 pm Email this article
Hypoglycemia, defined as having a blood sugar level of 69 mg/dl or less, increased the risk of dying from cancer by 2.3-fold (126%) during the next eight years in patients with coronary artery disease (CAD) compared to those with normal blood sugar levels of 80-109 mg/dl according to a 2004 study. Risk of Dying from Cancer
Risk of Dying from Cancer: 6.1% for hypoglycemics vs 2.9% for those with normal blood sugar
During the eight year follow-up, 6.1 percent of those with hypoglycemia died from cancer compared to 2.9 percent of those with normal blood sugar.
Subjects: 14,670 patients, 45-74 years-old
The study included 14,670 patients, 45- to 74-years-old, with coronary artery disease.
131 with hypoglycaemia (0.9%),
731 with low normal glucose (5%),
9308 euglycaemic (63.4%),
1577 with IFG (10.7%),
617 borderline diabetics (4.2%) and
2306 diabetics (15.7%),” the paper noted.
Conclusion: Hypoglycemia increases the risk of death in those with coronary artery disease
“Over a mean 8-year follow-up, hypoglycaemia emerges as a marker for substantially increased all-cause and cancer mortality among patients with [coronary artery disease] presenting with low fasting glucose levels,” the authors of the paper concluded.
“Actuarial survival curves showed the lowest mortality in euglycaemic [those with normal blood sugar levels of 80-109 mg/dl] and low normal groups [70-79 mg/dl]; the highest was seen in diabetic [140 mg/dl or greater] and hypoglycaemic patients [69 mg/dl or less].”
Fisman E, Motro M, Tenenbaum A, Leor J, Boyko V, Mandelzweig L, Sherer Y, Adler Y, Behar S. Is hypoglycaemia a marker for increased long-term mortality risk in patients with coronary artery disease? An 8-year follow-up. Eur J Cardiovasc Prev Rehabil. 2004 Apr, 11(2):135-43.
AUTHOR’S CONTACT INFORMATION
Cardiac Rehabilitation Institute
Chaim Medical Center
Tel-Hashomer, and Sackler Faculty of Medicine
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