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Intensive glucose-lowering treatment resulted in 4% HIGHER risk of death according to meta-analysis
Friday, October 14, 2011 10:25 am Email this article
Intensive glucose-lowering treatment does NOT lower the risk of death in Type 2 diabetics according to a meta-analysis of 13 studies.
The total risk of death was 4% HIGHER in those given intensive glucose-lowering treatment compared to those who were not given these treatments, however, the difference was not statistically significant, meaning this difference may be due to random chance. Cardiovascular Deaths
Cardiovascular Deaths 11% GREATER in the Intensive glucose-lowering treatment group
Intensive glucose-lowering treatment does NOT lower the risk of death from cardiovascular disease either.
The analysis found cardiovascular deaths were 11% GREATER in those given Intensive glucose-lowering treatment than those not, however, the difference was not statistically significant, meaning the difference might be due to random chance.
“Intensive treatment did not significantly affect all cause mortality (risk ratio 1.04, 99% confidence interval 0.91 to 1.19) or cardiovascular death (1.11, 0.86 to 1.43),” the wrote.
Subjects: 13 studies,34,533 patients, 18,315 received intensive glucose lowering treatment, 16,218 standard treatment
The analysis looked at 13 studies, with a total of “34,533 patients, 18,315 received intensive glucose lowering treatment and 16,218 standard treatment.”
Boussageon R, Bejan-Angoulvant T, Saadatian-Elahi M, Lafont S, Bergeonneau C, Kassai B, Erpeldinger S, Wright J, Gueyffier F, Cornu C. Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: Meta-analysis of randomised controlled trials. BMJ. 2011, 343:d4169.
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AUTHOR’S CONTACT INFORMATION
Centre d’Investigation Clinique
Hôpital Louis Pradel, 48
Avenue du Doyen Lépine
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