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  • Intensive glucose-lowering treatment INCREASED the risk of congestive heart failure by 47%

    Posted by .(JavaScript must be enabled to view this email address)
    Friday, October 14, 2011 10:10 am Email this article
    Intensive glucose-lowering treatment was found to INCREASE the risk a congestive heart failure by 47% in Type 2 diabetics according to a meta-analysis of 13 studies. Subjects

    Subjects: 13 studies,34,533 patients, 18,315 received intensive glucose lowering treatment, 16,218 standard treatment

    The analysis looked at 13 studies, with a total of “34,533 patients, 18,315 received intensive glucose lowering treatment and 16,218 standard treatment.”

    The analysis of congestive heart failure was limit to higher quality studies, however, they don’t say how many of the 13 studies were included.



    Conclusion: No benefit found on the risk of death with intensive glucose lowering treatment in Type 2 diabetics

    “The overall results of this meta-analysis do not show a benefit of intensive glucose lowering treatment on all cause mortality or cardiovascular death,” the authors concluded.

    “A 19% increase in all cause mortality and a 43% increase in cardiovascular mortality cannot be excluded.

    “The small benefit on non-fatal myocardial infarctions and microalbuminuria may be offset by a significant increase in the risk of severe hypoglycaemia.

    “The analysis, restricted to high quality studies, showed no benefit but a significantly increased risk of congestive heart failure in patients receiving intensive glucose lowering treatment.

    “In light of these findings, more high quality randomised trials assessing morbidity and mortality outcomes are warranted to establish the best approach for glucose lowering in people with type 2 diabetes.”


    Boussageon R, Bejan-Angoulvant T, Saadatian-Elahi M, Lafont S, Bergeonneau C, Kassai B, Erpeldinger S, Wright J, Gueyffier F, Cornu C. Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: Meta-analysis of randomised controlled trials. BMJ. 2011, 343:d4169.

    The full text of the article is posted here:


    Catherine Cornu
    Centre d’Investigation Clinique
    Hôpital Louis Pradel, 48
    Avenue du Doyen Lépine
    69500-Bron, France
    .(JavaScript must be enabled to view this email address)

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