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People given 3 mg of liraglutide per day lost 7.3 lbs more after two years than with orlistat
Monday, April 30, 2012 9:30 am Email this article
People given 3 mg of liraglutide per day lost 7.3 lbs more after two (2) years than those given the fat-blocking drug, orlistat, according to a recent study from Denmark. Liraglutide (brand name Victoza) is a human GLP-1 analog that is a once-daily injectable medication.
Diet and Exercise
Subjects given diet with 500 calorie deficit and exercise counseling
Subjects received a diet that 500 calories per day below their needs, and exercise counseling during a 2-week run-in.
Astrup A, Carraro R, Finer N, Harper A, Kunesova M, Lean M, Niskanen L, Rasmussen M, Rissanen A, Rossner S, Savolainen M, Van Gaal L. Safety, tolerability and sustained weight loss over 2 years with the once-daily human glp-1 analog, liraglutide. Int J Obes (Lond). 2011 Aug 16, published early on-line.
AUTHOR’S CONTACT INFORMATION
Prof Arne Astrup
The Department of Human Nutrition
Faculty of Life Sciences
University of Copenhagen
DK-1958 Frederiksberg, Denmark
Warning: Increases Risk of Thyroid Cancer
Warning: Liraglutide increases the risk of thyroid cancer
“Liraglutide injection may increase the risk that you will develop tumors of the thyroid gland, including medullary thyroid carcinoma (MTC; a type of thyroid cancer), which may cause death if it is not treated at an early stage,” notes the US National Library of Medicine’s website.
“If you develop thyroid cancer, your thyroid gland may need to be surgically removed.
“Tell your doctor if you or anyone in your family has or has ever had thyroid cancer, medullary thyroid carcinoma, or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2; condition that causes tumors in more than one gland in the body).
“If so, your doctor will probably tell you not to use liraglutide injection.
“If you experience any of the following symptoms, call your doctor immediately: lump or swelling in the neck; hoarseness; difficulty swallowing; or shortness of breath.”
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