People given 2.4 to 3 mg of liraglutide per day maintained weight loss of 17.6 lbs after two years

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Monday, April 30, 2012 10:10 am Email this article
People given either 2.4 mg or 3 mg of liraglutide per day maintained a weight loss of 17.6 lbs after two (2) years according to a recent study from Denmark. Liraglutide (brand name Victoza) is a human GLP-1 analog that is a once-daily injectable medication.

Diet and Exercise

Subjects given diet with 500 calorie deficit and exercise counseling

Subjects received a diet that 500 calories per day below their needs, and exercise counseling during a 2-week run-in.

REFERENCE

Astrup A, Carraro R, Finer N, Harper A, Kunesova M, Lean M, Niskanen L, Rasmussen M, Rissanen A, Rossner S, Savolainen M, Van Gaal L. Safety, tolerability and sustained weight loss over 2 years with the once-daily human glp-1 analog, liraglutide. Int J Obes (Lond). 2011 Aug 16, published early on-line.

AUTHOR’S CONTACT INFORMATION

Prof Arne Astrup
The Department of Human Nutrition
Faculty of Life Sciences
University of Copenhagen
Rolighedsvej 30
DK-1958 Frederiksberg, Denmark
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Warning: Increases Risk of Thyroid Cancer

Warning: Liraglutide increases the risk of thyroid cancer

“Liraglutide injection may increase the risk that you will develop tumors of the thyroid gland, including medullary thyroid carcinoma (MTC; a type of thyroid cancer), which may cause death if it is not treated at an early stage,” notes the US National Library of Medicine’s website.

“If you develop thyroid cancer, your thyroid gland may need to be surgically removed.

“Tell your doctor if you or anyone in your family has or has ever had thyroid cancer, medullary thyroid carcinoma, or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2; condition that causes tumors in more than one gland in the body).

“If so, your doctor will probably tell you not to use liraglutide injection.

“If you experience any of the following symptoms, call your doctor immediately: lump or swelling in the neck; hoarseness; difficulty swallowing; or shortness of breath.”

Articles on the same subject can be found here:

• Alii (orlistat) - (also see Xenical)

• Liraglutide

• Xenical (orlistat)