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    5-HTP increases leptin, carbidopa decreases


    Posted by .(JavaScript must be enabled to view this email address)
    Thursday, April 01, 2004 5:08 am Email this article
    5-Hydroxytryptophan (5-HTP) dose-dependently increases leptin in mice, however, pretreatment with carbidopa suppresses this increase according to a study from Kobe Pharmaceutical University in Kobe, Japan.

    Carbidopa is a decarboxylase inhibitor used to increase the amount of 5-HTP reaching the brain by preventing the conversion of 5-HTP to serotonin before reaching the brain.

    5-HTP is the immediate precursor to serotonin.

    The authors noted that the appetite-reducing effects of leptin are associated with a reduction of the naturally-occurring appetite-stimulants neuropeptide-Y, melanin-concentrating hormone and galanin.

    They also noted that leptin release is stimulated by glucocorticoids and insulin but inhibited by catecholamines.

    The authors concluded that “Our results show that the [appetite-reducing] effects of 5-HTP may be related to the elevation of circulating leptin levels.”

    Hopefully someone will follow-up with a study to determine which is better for appetite suppression—5-HTP alone or 5-HTP-plus-carbidopa—as well as verifying the results in humans.

    Contact information for the lead author is as follows:

    REFERENCE

    Yamada J; Sugimoto Y; Ujikawa M. The serotonin precursor 5-hydroxytryptophan elevates serum leptin levels in mice. Eur J Pharmacol, 1999 Oct 21;383(1):49-51.

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