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    Mice given high-fat diet 24-hours/day had 4X as much body fat as those limited to 8-hours/day


    Posted by .(JavaScript must be enabled to view this email address)
    Thursday, November 22, 2012 11:50 am Email this article

    Mice given access to a high-fat diet 24-hours per day 4-times as much body fat (18 grams vs 4.3 grams) as mice given access only 8-hours per day after 4.5 months even though both groups ate an equivalent number of calories.

    Limiting eating to only 8-hours per day is called time-restricted feeding.

    Time-restricted feeding of a high-fat diet causes metabolic changes which prevents obesity, Type 2 diabetes, fatty liver, inflammation and elevated insulin levels according to this study.

    Diet

    High-Fat Diet available 8-hours per day vs 24-hours per day

    Groups of mice were given access to a high-fat (61% fat) diet either 8-hours per day or 24-hours per day.

    Body Weight

    Mice given access to High-Fat Diet 24-hours per day weighed 38% more than mice given access to food 8-hours per day

    By the end of the 4.5 month study, the mice given access to a high-fat diet 24-hours per day weighed 38% more than the mice given access to the same high-fat diet only 8-hours per day.

    The weight of the mice given access to a high-fat diet 24-hours per day was 47 grams versus 34 grams for the mice given access to the same high-fat diet only 8-hours per day.

    Reference

    Hatori M, Vollmers C, Zarrinpar A, DiTacchio L, Bushong EA, Gill S, Leblanc M, Chaix A, Joens M, Fitzpatrick JA, Ellisman MH, and Panda S. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metab, 2012 Jun 6; 15(6): 848-860.

    Author’s Contact Info

    Satchidananda Panda
    Salk Institute for Biological Studies
    La Jolla, CA 92037, USA
    .(JavaScript must be enabled to view this email address)

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