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Time-restricted feeding (to 8-hours per day) increases release of fat from fat cells
Friday, November 23, 2012 8:50 am Email this article
Mice that were given access to a high-fat (61% fat) diet 24-hours per day showed a:
- disruption of fat oxidation
- impaired entry of fatty acids into the mitochondria (where they are burned for energy)
Whereas, mice that were given time-restricted access to the same high-fat diet only 8 hours per day (and fasted 16 hours per day) showed:
- an increase in fat being released from fat cells (an increase in lipolysis)
- increasing the breakdown of fat in the mitochondria (beta oxidation)
- increasing fat oxidation (the burning of fat)
- increasing energy expenditure (calories burned)
High-Fat Diet available 8-hours per day vs 24-hours per day
Groups of mice were given access to a high-fat (61% fat) diet either 8-hours per day or 24-hours per day.
Mice given access to High-Fat Diet 24-hours per day weighed 38% more than mice given access to food 8-hours per day
By the end of the 4.5 month study, the mice given access to a high-fat diet 24-hours per day weighed 38% more than the mice given access to the same high-fat diet only 8-hours per day.
The weight of the mice given access to a high-fat diet 24-hours per day was 47 grams versus 34 grams for the mice given access to the same high-fat diet only 8-hours per day.
Hatori M, Vollmers C, Zarrinpar A, DiTacchio L, Bushong EA, Gill S, Leblanc M, Chaix A, Joens M, Fitzpatrick JA, Ellisman MH, and Panda S. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metab, 2012 Jun 6; 15(6): 848-860.
Author’s Contact Info
Salk Institute for Biological Studies
La Jolla, CA 92037, USA
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