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Coenzyme Q10 cuts the risk of death in half in those with severe heart failure in 2 year study
Wednesday, June 05, 2013 10:55 am Email this article
In a 2-year study of patients with severe congestive heart failure, Coenzyme Q10 (CoQ10) cut the risk of death in half according to a new study.
In patients given CoQ10, 9% died versus 17% in those given a placebo.
The study found that the risk of death was reduced 2.1-fold after adjusting for things such as age.
CoQ10 Cuts Risk of First Major Adverse Cardiovascular Event in Half
CoQ10 cuts risk of first major adverse cardiovascular event in half over 2 years, from 25% to 14%
The risk of their first major adverse cardiovascular event was also cut in half in those given CoQ10.
14% in the CoQ10 group having an event within 2 years versus 25% in the placebo group.
Again, the hazard ratio was 2, so this must have been after adjustments for things such as age.
CoQ10 Should Be Added to Standard Heart Failure Therapy
CoQ10 should be added to standard heart failure therapy says Professor Mortensen
Professor Mortensen said:
“CoQ10 is the first medication to improve survival… should be added to standard heart failure therapy.”
CoQ10 Corrects A Deficiency In The Body In Heart Failure Patients
CoQ10 corrects a deficiency in the body in heart failure patients says Professor Mortensen
“Other heart failure medications block rather than enhance cellular processes and may have side effects. Supplementation with CoQ10, which is a natural and safe substance, corrects a deficiency in the body and blocks the vicious metabolic cycle in chronic heart failure called the energy starved heart.”
CoQ10 For People with Ischemic Heart Disease
‘I think ischaemic patients should supplement statin therapy with CoQ10’, says Professor Mortensen
They also noted that patients with ischaemic heart disease who use statins could also benefit from CoQ10 supplementation.
Professor Mortensen said:
“We have no controlled trials demonstrating that statin therapy plus CoQ10 improves mortality more than statins alone.
But statins reduce CoQ10, and circulating CoQ10 prevents the oxidation of LDL effectively, so I think ischaemic patients should supplement statin therapy with CoQ10.”
SA Mortensen, A Kumar, P Dolliner, et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure. Results from the Q-SYMBIO study. Presented at Heart Failure Congress 2013 Final Programme Number 440.
The full title of the Q-SYMBIO study is: “Coenzyme Q10 as adjunctive treatment of chronic heart failure: a randomised double blind multicentre trial with focus on changes in symptoms, biomarker status with BNP and long term outcome”.
In the movie “Statin Nation”, Peter Langsjoen, MD, who has been studying CoQ10 for more than 25 years, notes that statins lower CoQ10 by the same amount as they lowers cholesterol (40% or even 50%).
Ubiquinol is the BEST form of CoQ10
Ubiquinol leads to blood levels of CoQ10 which are 3-4 times higher than with the more common Ubiquinone
The best form of CoQ10 is called Ubiquinol rather than the more common form of Ubiqunone.
(Here is how I remember which form of CoQ10 is best. Ubiquinol sounds like Ubiquin-ALL, and I want to use the form of CoQ10 that has “ALL” the benefits.)
In an interview that Julian Whitaker, MD did on his radio program, Peter Langsjoen, MD, a cardiologist and CoQ10 researcher who has been researching CoQ10 for 25 years, said Ubiquinol is absorbed better than Ubiqunone and leads to higher blood levels.
He notes that they found that 300 mg of Ubiquinol increased blood levels of CoQ10 3-4 times more than when they gave the same dose of the more common form, Ubiqunone.
A 6-minute audio clip from the interview with
Peter Langsjoen, MD talking about this is attached
In the interview, cardiologist and CoQ10 researcher, Peter Langsjoen, MD says,
“Yes, it [CoQ10, ubiquinol] fundamentally improves heart function and decreases heart size.”
Dr. Whitaker says,
“If the pharmaceutical companies and conventional medical [doctors] were working to improve the health of their patients, patent or no patent, this is one of the most significant discoveries of the last century.”
Dr. Langsjoen say, “[Yes,] I think so.”
“One thing that your audience should appreciate is that we initially viewed this [in the late 1970’s and early 1980’s] this as a relatively simple deficiency state.”
“A good analogy would be beriberi which is a form of heart failure related being deficient in vitamin B1, thiamine.
“If you give even small amounts of supplemental thiamine [vitamin B1], you completely prevent and treat that type of nutritional heart failure.
“We thought early on, around the late-1970s and early-1980s, that if…
we knew that CoQ10 levels were lower in blood and in muscle.
“We thought if we just gave enough CoQ10 to get the levels normal, it should work, that we would have corrected this deficiency state and their heart would be better.
“It was a nice simple thought, but it didn’t work.
“Over a period of following about 126 patients with heart failure, and we really followed them, we saw them every 3 months for 6 years,
it became clear that the people who got better had to have blood levels that were 2.5 times normal.
“Not just normal, normal wasn’t good enough, they wouldn’t get better.
“We now appreciate it when you give supplemental CoQ10,
you have to have blood levels…
we prefer to have have them up above 3.5 [μg/ml].
“The Germans of done some beautiful work showing that at that threshold,
CoQ10 starts to get taken up really well by cells.
“So when treating heart failure patients,
it’s important to realize that these levels have to be adequate to work.
“There have been 23 controlled studies of CoQ10 and heart failure since 1972 to last year .
“20 showed clear benefits.
“3 showed no benefits.
“One of the 3 studies did not measure CoQ10 levels, so we have no way of knowing [if they gave enough CoQ10 or not.]
“Two [other studies], and unfortunately these are the most commonly cited by American cardiologists as evidence of that CoQ10 is not effective in heart failure…
“One was an Australian study.
“Their treatment blood levels of people on CoQ10 was a mean of 1.7 [μg/ml].
“It won’t work at 1.7 [μg/ml].
“The 2nd [study] by Gottlieb and Khatta, their CoQ10 mean levels was a little better at around 2 [μg/ml],
but [blood levels of CoQ10 were] still inadequate.
[Reference: Meenakshi Khatta, MS, CRNP; Barbara S. Alexander, MD, PhD; Cathy M. Krichten, MS, CRNP; Michael L. Fisher, MD; Ronald Freudenberger, MD; Shawn W. Robinson, MD; and Stephen S. Gottlieb, MD. The Effect of Coenzyme Q10 in Patients with Congestive Heart Failure. Annals of Internal Medicine 18 April 2000 | Volume 132 Issue 8 | Pages 636-640.]
“There have been to beautiful controlled trials done by the Italians,
the most recent was in 2006 [published in] the European Heart Journal,
and [it] showed very clear significant improvement
in heart failure versus placebos…
a nice controlled trial…
and their treatment [blood] levels [of CoQ10] was 3.6 [μg/ml].
“Therefore, blood levels [of CoQ10] makes a difference.
“If you have any cardiovascular disease,
or your family has any cardiovascular disease,
you should be taking Coenzyme Q10
[Ubiquinol rather than the more common ubiquinone],
perhaps at least 100 to 300 mg [per day] says Dr. Whitaker.
[In his study of end-stage heart failure patients,
Dr. Langsjoen used “an average of
580 mg/day of ubiquinol (450-900 mg/day)”.]
Study Finds Ubiquinol Increased CoQ10 Blood Levels 4-fold vs Ubiquinone
Ubiquinol increases blood levels of CoQ10 4-fold higher than with Ubiquinone in heart failure patients, ejection fraction increased from 22% to 39%
Here is the paper by Peter Langsjoen, MD, who has been researching CoQ10 for 25 years, which reports that when seven (7) patients with congestive heart failure were switched from an average of 450 mg of ubiquinone daily (150–600 mg/day) to an average of 580 mg/day of ubiquinol (450–900 mg/day), plasma levels of CoQ10 increased from an average of 1.6 μg/ml
to 6.5 μg/ml—a 4-fold increase—and ejection fraction increased from 22% to 39%.
Langsjoen PH, and Langsjoen AM. Supplemental ubiquinol in patients with advanced congestive heart failure. Biofactors, 2008; 32(1-4): 119-128.
Author’s Contact Info
Author’s Contact Info
Peter Langsjoen, MD
East Texas Medical Center and
Trinity Mother Francis Hospital, TX, USA
Patients with CHF, NYHA class IV, often fail to achieve adequate plasma CoQ10 levels on supplemental ubiquinone at dosages up to 900 mg/day.
These patients often have plasma total CoQ10 levels of less than 2.5 μg/ml and have limited clinical improvement.
It is postulated that the intestinal edema in these critically ill patients may impair CoQ10 absorption.
We identified seven patients with advanced CHF (mean EF 22%) with
sub-therapeutic plasma CoQ10 levels with mean level of 1.6 μg/ml
on an average dose of 450 mg of ubiquinone daily (150–600 mg/day).
All seven of these patients
were changed to an average of
580 mg/day of ubiquinol (450–900 mg/day)
with follow-up plasma CoQ10 levels, clinical status, and EF measurements by echocardiography.
Mean plasma CoQ10 levels
1.6 μg/ml (0.9–2.0 μg/ml)
6.5 μg/ml (2.6–9.3 μg/ml).
[Hobbs: A 4-fold increase in plasma CoQ10 levels when using ubiquinol versus ubiqunone.]
Mean EF [ejection fraction] improved
from 22% (10–35%)
up to 39% (10–60%)
and clinical improvement has been remarkable with NYHA class improving from a mean of IV to a mean of II (I to III).
Ubiquinol has dramatically improved absorption
in patients with severe heart failure
and the improvement in plasma CoQ10 levels is correlated with both clinical improvement and improvement in measurement of left ventricular function.
Statins Block Production of CoQ10
Statins block production of CoQ10, reduce CoQ10 by 40-50%, the same amount they lower LDL cholesterol
In the documentary “Statin Nation”, Peter Langsjoen, MD, a cardiologist and CoQ10 researcher, explains that statins block a biochemical pathway, very high up in the pathway, blocking a compound called Mevalonate, which blocks production of cholesterol and CoQ10 [and Dolichol.]
Dr. Langsjoen says:
“There are many branches on this pathway.
“Think of it [this pathway] like a tree,
and you are cutting it off at the trunk.
“All the branches will be affected…”
“If you take a statin and
decrease cholesterol levels by… 40% or even 50%...
you’re going to have a 40% or 50% reduction in CoQ10.
“It’s not avoidable.
It’s the same pathway.
“So cells that are active
24-hours per day, every day, very active,
and that would be heart muscle cells
—they don’t rest day or night—
they use a huge amount of energy,
heart muscle has
the highest concentration of CoQ10 by far.”
[So the heart muscle is affected
by this decrease in CoQ10 levels
which are necessary for energy production / production of ATP.]
—Peter Langsjoen, MD
“By giving a statin to reduce cholesterol,
we may well be blocking
one of the most important molecules
in the function of heart muscle [CoQ10].
“So in effect, while statins my be acting, they think, in a good way,
we’ve got very ample evidence that
by blocking CoQ10
we are probably raising the risk of
heart muscle failure,
and therefore heart attacks from a different avenue
other than arterial blockage.”
—Dr. Rajendra Sharma
“Most drugs, if they are going to affect you adversely,
you can tell it within a day.
You swallow the pill, and 30 minute later,
you throw up or have diarrhea or have a rash.
“Then you know not to take it again.
“But statins are insidious because
their side effects begin very gradually
over a period of months to years.”
—Peter Langsjoen, MD
Desiccated Thyroid Can Cure Congestive Heart Failure
Desiccated thyroid can cure some cases of congestive heart failure as noted by Mark Starr, MD
I am even MORE impressed with desiccated thyroid curing congestive heart failure as described by Mark Starr, MD in his book “Hypothyroidism, Type 2”, and the Before and After pictures he shows in his book from old medical journals showing enlarged hearts shrinking back to normal size within a couple of months after people started taking desiccated thyroid.
Desiccated Thyroid Cured Heart Failure in Dr. Starr’s Father
Mark Starr, MD’s father’s enlarged heart was cured with desiccated thyroid
A one-minute audio clip of Mark Starr, MD, author of “Hypothyroidism, Type 2: The Epidemic” tells a short story about his father is posted
Dr. Starr says:
“My father was 80.”
“He had congestive heart failure… a great big heart [ enlarged heart ].”
“He was losing his great sense of humor… he was an intellectual fellow.”
“His eyes were starting to get a little cloudy.”
“I returned from New York about that time.”
“I got him on testosterone as well as desiccated thyroid.”
“By the time of his death, after a disaster during knee replacement surgery 6 years later, they could not believe it was [ NOT ] his heart that [ was ] contributing [ to his death ].”
“His coronary catheter showed 50% ejection fraction… normal heart size… minimal atherosclerosis… and he had regained his sense of humor and intellect within about 12 to 18 months of starting [testosterone and thyroid].”
“My mother thanked me many times for giving her husband back to her.”
More Info on Desiccated Thyroid Curing Heart Failure
More Info on Desiccated Thyroid Curing Heart Failure from Mark Starr, MD’s book ‘Hypothyroidism, Type 2, The Epidemic’
Here is additional info
from Mark Starr, MD’s book
“Hypothyroidism, Type 2, The Epidemic”
about curing congestive heart failure with desiccated thyroid.
In 1918 It Was Discovered That Desiccated Thyroid Can Cure Heart Failure
More Info on Desiccated Thyroid Curing Heart Failure from Mark Starr, MD’s book ‘Hypothyroidism, Type 2, The Epidemic’
Mark Starr, MD notes that this was discovered by
Dr. Zondek in 1918
that desiccated thyroid could cure heart failure,
but seems to have been forgotten.
He notes there are more than 500,000 new cases of congestive heart failure diagnosed every year, and half of these patients will die within 5 years of their initial diagnosis.
The Heart Muscle Is Profoundly Affected By Hypothyroidism
The heart muscle is profoundly affected by hypothyroidism notes Mark Starr, MD
Dr. Starr writes:
“The heart muscle is profoundly affected by hypothyroidism.
“Throughout all of my years of formal medical training, not once did I witness the successful treatment of Congestive Heart Failure with thyroid hormones.”
“I have since learned to expect resolution of congestive heart failure after treatment with desiccated thyroid.”
—Starr, Hypothyroidism, Type 2, page 128 (page attached)
Congestive Heart Failure Linked With Hypothyroidism in 1918
Desiccated thyroid shrank the enlarged heart to normal size within weeks
“In 1918, Dr. Zondek was the first to publish a report that linked congestive heart failure with hypothyroidism.
“The enlarged heart is shown to shrink to normal size within weeks of treatment [with desiccated thyroid].
“The patient’s symptoms associated with heart failure as well as hypothyroidism, resolved.
“News of Zondek’s success spread quickly.
—Starr, Hypothyroidism, Type 2, page 129 (page attached)
Verification that Desiccated Thyroid Had Shrank An Enlarged Heart
Desiccated thyroid shrank the enlarged heart within weeks, and the heart enlarged again once desiccated thyroid was stopped
“Dr. Rigler… described this characteristic appearance of the heart, “enormously dilated in all chambers.”
“Normalization of the heart size followed treatment with thyroid hormones.
“The following X-ray showed the heart’s dramatic return to normal size.
“To demonstrate that the thyroid hormones were responsible…
the hormones were stopped for 6 weeks.
“The 4th X-ray shows the heart beginning to enlarge.
“Thyroid hormones were restarted, and the heart size normalized once again.”
—Starr, Hypothyroidism, Type 2, page 130 (page attached)
Desiccated Thyroid Shrank An Enlarged Heart in 2.5 Months
Enlarged heart shank in 10 weeks with desiccated thyroid
“Sixty-eight (68) days [ 10 weeks ]
after beginning thyroid medication,
heart returned to normal size.”
—Starr, Hypothyroidism, Type 2, page 131 (page attached)
Six weeks after stopping thyroid, the heart was enlarging again
Five weeks after restarting desiccated thyroid, the heart was normal size again
“Six weeks after thyroid stopped,
the heart was enlarging again.
“Five weeks after restarting thyroid,
heart returned to normal size again.”
—Starr, Hypothyroidism, Type 2, page 132 (page attached)
Ignored for 95 years
This amazing discovery that desiccated thyroid can shrink an enlarged heart and cure heart failure has been ignored
“Renowned modern medical texts on hypothyroidism prominently mention its affect on the heart.
‘… cardiac output is… decreased, often to one-half the normal value.’
“The successful treatment of heart failure espoused
by Dr. Zondek… and many others from the first half of the 20th Century
has been neglected for over 80 years.
“Dr. Zondek’s textbook,
The Disease of the Endocrine Glands,
provided the most detailed descriptions regarding the effect of
hypothyroidism on circulation and the heart.
“Dr. Zondek addressed the treatment of heart failure due to hypothyroidism in the following excerpt,
“Ultimately the heart may return to its normal size
[ after treatment with thyroid hormones . ]
“This has been confirmed by Assmann; Curschmann; Meissner; Fahr; Mussio; Fournier; Means, White and Krantz; Lerman, Clark and Means; Werner; Morales; and others.
Only the widening of the aorta remains irreparable…”
—Starr, Hypothyroidism, Type 2, page 133 (page attached)
The Story of Mark Starr, MD’s Father With An Enlarged Heart
Mark Starr, MD’s father’s enlarged heart returned to normal size after 4 years on desiccated thyroid
On page 135, Mark Starr, MD tells a short story of
his 86-year-old father who developed congestive heart failure,
had a heart the size of a volleyball,
which returned to normal size after 4 years with desiccated thyroid.
Starr goes on to say:
“Palpitations, increased or decreased heart rate, preventricular contractions, artial fibrillation, and other conduction problems are common [ in patients with hypothyroidism ].
“Many of my [hypothyroid] patients suffered frequent preventricular contractions as well as other arrhythmias.
“The ones who persevered and
finally receive adequate dosages of desiccated thyroid
[ 2 to 5 grains, average being
3 to 3.5 grains as he notes elsewhere in the book ]
saw their heartbeats normalize.”
—Starr, Hypothyroidism, Type 2, page 135 (page attached)
Angina Rare in Patients Treated with Desiccated Thyroid
Angina rare in Broda Barnes, MD’s patients treated with desiccated thyroid
“Angina… was as rare as pneumonia
in Dr. [Broda] Barnes’ treated patients
[ treated with desiccated thyroid ].
“He [Broda Barnes] discusses this in his book,
Heart Attack Rareness in Thyroid Treated Patients, which was published in 1972.
“Yet, Dr. Barnes studies remain neglected by cardiovascular doctors 30 years later [ 41 years now ].
—Starr, Hypothyroidism, Type 2, page 136 (page attached)
Contact Info for Dr. Starr
Mark Starr, MD’s contact info
Here is Mark Starr’s contact information.
I encourage everyone to read Mark Starr’s book “Hypothyroidism Type 2: The Epidemic” or Broda Barnes Book “Hypothyroidism: The Unsuspected Illness”. Barnes was an thyroid expert like few others.
Amazon.com: Hypothyroidism Type 2: The Epidemic (9780975262405): Mark Starr: Books
Amazon.com: Hypothyroidism: The Unsuspected Illness (9780690010299): Broda Barnes: Books
A Simple Explanation Why Desiccated Thyroid Can Cure Congestive Heart Failure
Desiccated thyroid increases the number and activity of the mitochondria, correcting the energy problem
The reason for this, that is that desiccated thyroid can cure some forms of congestive heart failure, seems to be simple and straight-forward.
1. Thyroid hormones increase the number and activity of the mitochondria.
Dr. Starr notes that in all of his research on thyroid, this was his epiphany—that the problem in hypothyroidism is how it affects mitochondria. (It’s an energy problem.)
2. Thus, hypothyroidism decreases the number and activity of the mitochondria.
3. Mitochondria make up one-third of the weight of the heart.
4. Hypothyroidism can decrease cardiac output by 50%, Dr. Starr notes in another audio clip.
5. Thus, the heart becomes enlarged to try and keep up demands of the body. (It’s an energy problem.)
6. Giving desiccated thyroid increases the number and activity of the mitochondria—it corrects the energy problem.
7. This is why desiccated thyroid helps the heart shrink back to normal size. (Desiccated thyroid corrects the energy problem.)
I will be glad to re-send anyone the email showing the Before and After pictures from his book showing this, and what Starr writes about this.
This is the first thing I would try if I had congestive heart failure.
What is the harm in trying this?
It seems to me that the risk of trying this is VERY LOW—
a very low risk with a very high reward.
Mark Starr, MD also told a story about his father having congestive heart failure, having a great big heart, and Mark giving his father both testosterone and desiccated thyroid, and when his father died several years later from complications from surgery (knee surgery, maybe?)—the surgery had nothing to do with his heart—doctors were shocked to find that his heart had nothing to do with his death.
Starr notes that one of the actions of thyroid hormones is to increase mitochondria, so it makes perfect sense to me that this can make the heart stronger and cause it to shrink back to normal size.
Several months ago, the Life Extension Foundation had an article on mitochondrial diseases.
It was very interesting because the conditions they talked about which were related to mitochondrial problems, were the EXACT SAME conditions that Mark Starr, MD wrote about in his book on Type 2 Hypothyroidism—the idea that some people suffer from hypothyroidism even though TSH levels are normal and blood levels of thyroid hormone levels are normal.
Type 2 Hypothyroidism Defined
Type 2 Hypothyroidism is where thyroid blood levels are normal, but there is a cellular resistance to thyroid hormones
Starr believes this is due to a cellular resistance of thyroid hormones, similar to Type 2 diabetes.
Mark Starr, MD discovered this based on his personal experience— feeling tired and his muscles aching when he was in his 40’s, and his cholesterol levels had increased from 160 when in medical school to 240 when he was in his 40’s, and he had been told that his thyroid was fine based on his TSH levels, but all of his symptoms resolved and his cholesterol levels fell back down to 150 or 160 after he started taking desiccated thyroid—3 or 3.5 grains.
Stephen Langer, MD Had a Similar Experience
Stephen Langer, MD, author of another book on hypothyroidism, had a similar experience; his thyroid blood levels were normal, but his fatigue resolved when he took desiccated thyroid
Stephen Langer, MD, author of another book on Hypothyroidism, has told a very similar story—feeling tired all the time in his 40’s and not being able to figure out what was wrong—but this resolved after he started taking desiccated thyroid after he interviewed thyroid expert, Broda Barnes, MD, PhD on his radio program.
Thyroid Blood Tests Are Unreliable
Broda Barnes, MD, PhD found thyroid blood tests are unreliable
It is exactly the same story that Broda Barnes, MD, PhD tells in his 1976 book “Hypothyroidism, The Unsuspected Illness” (1976).
Barnes said that he had found that thyroid blood tests were unreliable, and he found that many patients with symptoms for which he could not find a cause based on all the tests he was taught to do in medical school, resolved when he gave these patients desiccated thyroid.
Barnes’s background is unique in that he got his PhD in physiology, and was assigned to study the thyroid gland, removing the thyroid gland of baby rabbits, and then watching all of the physical manifestations of this.
So when he started practicing medicine, he said he saw patients who had complaints for which he could not find anything wrong, but the complaints reminded him of the baby rabbits who had their thyroid gland removed, which is why he tried giving patients desiccated thyroid, and from the success of doing this, he determined that thyroid blood tests were unreliable.
The Life Extension Foundation’s article on mitochondrial diseases never mention that any of these conditions might be related to hypothyroidism.
Contact Info for Julian Whitaker, MD
Julian Whitaker, MD’s contact info
Julian Whitaker, MD
Whitaker Wellness Institute
Attention: Patient Services
4321 Birch St.
Newport Beach, CA 92660
Located right next to John Wayne—Orange County Airport
In the United States and Canada, (800) 488-1500
All others please call (949) 851-1550
Contact Info for CoQ10 researcher, Peter Langsjoen MD
Peter Langsjoen, MD’s contact info
Peter H. Langsjoen MD
East Texas Medical Center
1107 Doctors Drive
Tyler, TX 75701
(903) 595-3778 phone
(903) 595-4962 fax
Julian Whitaker, MD has also told a story on his radio program about how CoQ10 is great for Congestive Heart Failure.
He had one young patient who was on a list for a heart transplant because of a very low ejection fraction.
He had the patient take large doses of CoQ10 ( and D-Ribose which the body uses to make ATP, and something else, I think ).
The patient’s ejection fraction increased to normal and he was taken off the transplant list.
Several years later, the boy, who I think was now in his mid-20’s, stopped taking the CoQ10 and the two other things Dr. Whitaker has suggested, and his ejection fraction fell again, and again he was put on a list for a heart transplant.
His mother called Dr. Whitaker and asked what to do.
Dr. Whitaker asked if her son was still taking the CoQ10.
She said, no, he had stopped taking it.
So he started taking CoQ10 again, and once again, his ejection fraction increased to normal, and he came off the heart transplant list.
And this seems like such a safe and inexpensive thing, that surely this should be the first thing to try.
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