fatnews.com Home page  >  Article | Previous article | Next article

SEARCH

QUICKLINKS AND VIEW OPITONS

  • Categories of Articles
  • Summary View
  • Headline View
  • Archive of Quotes
  • Contact Us
  • Follow @fatnews

    Long-term treatment with antibiotic caused weight gain of 4 to 29 lbs in one-fourth of patients


    Posted by .(JavaScript must be enabled to view this email address)
    Tuesday, July 10, 2018 12:57 pm Email this article

    One-fourth (23%) of patients treated long-term with the antibiotic, doxycycline (100 mg twice a day), plus the antimalarial drug, hydroxychloroquine (600 mg daily), gained from 4 to 29 lbs after one-year according to a study from France.

     

    Treatment reduced 3 gut bacteria

    Treatment was associated with lower concentrations of three gut bacteria, Bacteroidetes, Firmicutes and Lactobacillus.

    Conclusion: Long-term doxycycline may cause significant weight gain

    “[This suggests] that long-term doxycycline treatment lead to significant changes in weight in [some people and is associated with changes in gut bacteria],” the authors concluded.

    “These results are consistent with previous studies showing that doxycycline is associated with weight gain in undernourished children in developing countries and in healthy US army recruits.”

    Subjects

    Subjects: 82 people

    The study included a total of 82 people, 48 patients with Q fever endocarditis that were treated with doxycycline plus hydroxychloroquine and 34 controls.

    The average age of patients was 55-years-old.

    Sixty percent (60%) of the study group were males.

    Reference

    Angelakis E, Million M, Kankoe S, Lagier J-C, Armougom F, Giorgi R, and Raoult D. Abnormal weight gain and gut microbiota modifications are side effects of long-term doxycycline and hydroxychloroquine treatment. Antimicrobial Agents and Chemotherapy, 2014 Mar 31; Published on-line ahead of print. http://aac.asm.org/content/early/2014/03/25/AAC.02437-14

    Author’s Contact Info

    Didier Raoult
    URMITE
    Aix Marseille Université
    UMR CNRS 7278, IRD 198, INSERM 1095
    Faculté de Médecine
    27 Bd Jean Moulin
    13005 Marseille, France
    .(JavaScript must be enabled to view this email address)

    Articles on the same subject can be found here:


    COMMENTS

    Please feel free to share your comments about this article.


    Name:

    Email:

    Comments:

    Please enter the word you see in the image below:


    Remember my personal information

    Notify me of follow-up comments?



    © Copyright 2003-2021 - Larry Hobbs - All Rights Reserved.