Prolonged use of statins associated with a 23% increased risk of colorectal cancer

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Wednesday, August 01, 2018 8:47 am Email this article

Prolonged use of statins for more than 4 years was associated with a 23% increased risk of colorectal cancer according to a recent analysis of data from 574 UK general practices from 1998-2008.

Prolonged use of atorvastatin (Lipitor) for more than 4 years was associated with a 51% increased risk of colorectal cancer.

 

Data

Data from 574 UK general practices from 1998-2008

“A series of nested case-control studies was conducted covering 574 UK general practices within the QResearch database,” the paper notes.

“Cases were patients with primary cancers diagnosed between 1998 and 2008.

“The associations between statin use and risk of ten site-specific cancers were estimated with conditional logistic regression adjusted for co-morbidities, smoking status, socio-economic status, and use of non-steroidal anti-inflammatory drugs, cyclo-oxygenase-2 inhibitors and aspirin.

“88125 cases and 362254 matched controls were analysed.”

Reference

Vinogradova Y, Coupland C, and Hippisley-Cox J. Exposure to statins and risk of common cancers: a series of nested case-control studies. BMC Cancer, 2011; 11: 409.

Author’s Contact Info

Yana Vinogradova
Division of Primary Care
13th floor, Tower Building
University Park
Nottingham, NG2 7RD, UK.
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