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  • Statins can cause congestive heart failure


    Posted by .(JavaScript must be enabled to view this email address)
    Tuesday, July 19, 2016 12:20 pm Email this article

    Statins can cause congestive heart failure by depleting coenzyme Q10 (CoQ10) and ‘heme A’ which reduces production of adenosine triphosphate (ATP) according to a 2015 review paper by Prof. Harumi Okuyama from Nagoya City University in Nagoya, Japan, Peter H. Langsjoen MD, a cardiologist from Texas, and others who reviewed more than 20 statin drug studies done after 2004.

    Statin-related heart failure

    Statin-related heart failure first published in 1990

    “The first reported cases of statin-related heart failure were published in 1990.”

    “Five previously stable cardiomyopathic patients had a dramatic deterioration in myocardial function measurements and in clinical status shortly after beginning lovastatin.”

    CoQ10 Helps

    Patients suffering from statin-induced heart failure helped with 100-200 CoQ10

    “These patients returned to prestatin condition after stopping their statin therapy and doubling their supplemental CoQ10 from 100 to 200 mg/day.

    Statins cause diastolic dysfunction

    Statins cause diastolic dysfunction in 10 of 14 healthy people

    “In 2004, it was demonstrated that diastolic dysfunction developed in 10 of 14 healthy hyperlipidemic subjects after 3–6 months of atorvastatin [Lipitor] at 20 mg/day.

    “Impairment in the ATP-dependent process of diastole is an early finding in congestive heart failure.

    CoQ10 helps with diastolic dysfunction

    300 mg per day of CoQ10 helps with diastolic dysfunction

    “In this study, the early diastolic dysfunction was asymptomatic and reversed to normal after 3 months of supplemental CoQ10 at 300 mg/day, while the patients continued to take their statin therapy.

    Statin-related heart failure

    Statin-related heart failure first published in 1990

    “In contrast to this mild asymptomatic impairment in heart muscle function, in an ongoing study, patients who have been on statin treatment for an average of 6 years presented with overt and often permanent congestive heart failure,” the paper notes.

    50 Patients with Severe Statin Side Effects

    One-fourth of these patients had evidence of congestive heart failure

    “In 2005, 50 consecutive patients presenting with severe statin side effects were followed up for a mean of 28 months [39].

    “In addition to symptoms of muscle pain and weakness, fatigue, dyspnea, peripheral neuropathy and memory loss, roughly one-fourth of these patients had evidence of congestive heart failure at the time of presentation.

    CoQ10 Given to These Patients

    240 mg per day of CoQ10 Helped Patients Improve Dramatically

    “All 50 patients had their statin drug discontinued due to side effects and all were supplemented with an average of 240 mg of CoQ10 per day and followed up for 2 years.

    “The patients’ chief complaints improved dramatically and 50% of those with heart failure showed significant improvement in heart muscle function.

    “There were no adverse effects from statin drug discontinuation with no myocardial infarctions or strokes and no side effects from CoQ10 supplementation.

    Statin-Induced Heart Muscle Problems Are Not Uncommon

    130 cases seen in one cardiology practice in 4 years

    “Our current experience with statin cardiomyopathy indicates that it is not at all uncommon, with 130 cases identified during a 4-year period of time presenting to a solo cardiology practice.

    Statin-Induced Problems Are Not Being Recognized

    Statin-Induced Heart Muscle Problems Are Not Being Recognized

    “Although the impairment in heart muscle function, secondary to statin therapy, appears to be common after long-term (average 6 years) statin drug therapy, it is clear that it is not being recognized.”

    “In the words of Robertson Davies, ‘The eyes see only what the mind is prepared to comprehend’.”

    Physicians Are Not Aware

    Physicians Are Not Aware That Statin Can Cause Heart Failure

    “Physicians in general are not aware that statins can cause heart failure and are clearly not recognizing it.”

    Statin-Induced Heart Failure Often Attributed to Aging

    Statin-Induced Heart Failure Usually Attributed to Something Else Such As Aging

    “Although vast majority of physicians readily recognize and diagnose heart failure in patients taking statins, the heart failure is almost always attributed to other non-statin-related factors, such as aging, hypertension and coronary artery disease.”

    “Furthermore, it is difficult to recognize any adverse drug effect when it is delayed by several years.”

    Statin-Induced Heart Failure Often Attributed to Aging

    Statin-Induced Heart Failure Related to Impaired Mitochondrial Function

    “The mechanism for the impairment in heart muscle function appears to be related to impaired mitochondrial function, which in turn is related to statin depletion of CoQ10, selenoproteins and ‘heme A’, all required for normal mitochondrial function.”

    Prof. Harumi Okuyama: ‘I cannot find any evidence to support people taking statins and patients who are on them should stop’

        “We have collected a wealth of information on cholesterol and statins from many published papers and find overwhelming evidence that these drugs accelerate hardening of the arteries and can cause, or worsen, heart failure.
        “I cannot find any evidence to support people taking statins and patients who are on them should stop,” Prof. Harumi Okuyama from Nagoya City University in Nagoya, Japan, lead author of the 2015 review paper of statin trials, was quoted as saying in the UK newspaper The Daily Express.

    Peter Langsjoen, MD: ‘These drugs [statins] should never have been approved for use.’

        “These drugs [statins] should never have been approved for use.
        “The long-term effects are devastating,” Peter Langsjoen, MD, a cardiologist from Texas and coauthor of this 2015 review paper, was quoted as saying in the UK newspaper The Daily Express.

    Dr. Malcolm Kendrick: ‘The harms [of statins] clearly outweigh any previously suggested benefits’

        “This study demolishes the argument that these drugs should be prescribed to anyone, as the harms clearly outweigh any previously suggested benefits,” Dr. Malcolm Kendrick, author of The Great Cholesterol Con who has studied cardiovascular disease and statins for many years, was quoted as saying in the UK newspaper The Daily Express.

    This article was originally posted on Jan 11, 2016.

     

     

    Reference

    Okuyama H, Langsjoen PH, Hamazaki T, Ogushi Y, Hama R, Kobayashi T, and Uchino H. Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms. Expert Rev Clin Pharmacol, 2015 Feb 6; 1-11.

    Author’s Contact Info

    Harumi Okuyama
    Nagoya City University and
    Institute for Consumer Science and Human Life
    Kinjo Gakuin University
    2-1723 Omori, Moriyama
    Nagoya 463-8521, Japan
    Tel.: +81 528 763 840
    Fax: +81 528 763 840
    .(JavaScript must be enabled to view this email address)

    Peter H. Langsjoen MD
    East Texas Medical Center
    1107 Doctors Drive
    Tyler, TX 75701
    (903) 595-3778 phone
    (903) 595-4962 fax
    .(JavaScript must be enabled to view this email address)



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