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Diet-induced weight loss reduces inflammation associated with an chronic diseases and death
Monday, April 12, 2004 10:42 am Email this article
"Persistent, low-grade inflammation is an independent predictor of several chronic diseases and all-cause mortality," according to a new study from researchers at Wake Forest University School of Medicine. However, diet-induced weight reduces this inflammation the study finds. "[D]ietary intervention designed to elicit weight loss reduces overall inflammation in older, obese persons," the authors conclude.
The study consisted of 316 overweight or obese men and women who were 60 or older who had osteoarthritis of the knee.
They were randomly assigned to one of four treatments for 1.5 years.
The four treatments were:
- Healthy lifestyle control
- Diet-induced weight loss
- Diet plus exercise
Exercise consisted of combined weight training and walking for one hour 3 times per week.
The diet-induced weight-loss consisted of a weekly session with a registered dietitian to provide education and support for lowering calorie intake.
The diet-induced weight-loss resulted in significantly greater reductions in concentrations of markers for inflammation than the no weight loss group.
The markers for inflammation included C-reactive protein, interleukin 6, and soluble tumor necrosis factor receptor 1.
Changes in soluble tumor necrosis factor receptor 1 correlated with changes in body weight, but changes in C-reactive protein and interleukin 6 did not.
Exercise training did not have a significant effect on these inflammatory biomarkers, however, the amount of exercise in this study did not cause weight loss.
Nicklas BJ, Ambrosius W, Messier SP, Miller GD, Penninx BW, Loeser RF, Palla S, Bleecker E, Pahor M. Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial. Am J Clin Nutr. 2004 Apr, 79(4):544-51.
To request a copy of this study contact:
B. J. Nicklas
Section on Gerontology and Geriatric Medicine and Center for Human Genomics
Wake Forest University Medical Center
Medical Center Boulevard
Winston-Salem, NC 27157
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