Long-term statin use is associated with double the risk of breast cancer
Thursday, June 09, 2016 8:29 am Email this article
Long-term statin use is associated with double the risk of breast cancer according to a 2013 study.
Current users of statins for 10 years or longer had a 1.8-fold increased risk of invasive ductal carcinoma and a 2-fold increased risk of invasive lobular carcinoma compared with never users of statins.
Among women diagnosed with hypercholesterolemia, current users of statins for 10 years or longer had 2-times the risk of invasive ductal carcinoma and 2.4-times the risk of invasive lobular carcinoma compared with never users.
“In this contemporary population-based case-control study, long-term use of statins was associated with increased risks of both [invasive ductal carcinoma] and [invasive lobular carcinoma],” the authors of the study concluded.
80% of Breast Cancers are Invasive ductal carcinoma, 10% are Invasive lobular carcinoma
“We used data from a population-based case–control study of breast cancer conducted in the Seattle–Puget Sound region to investigate the relationship between long-term statin use and breast cancer risk,” the paper notes.
“Nine hundred sixteen invasive ductal carcinoma (IDC) and 1,068 invasive lobular carcinoma (ILC) cases in patients 55 to 74 years of age diagnosed between 2000 and 2008 were compared with 902 control women.
“All participants were interviewed in-person and data on hypercholesterolemia and all episodes of lipid-lowering medication use were collected through a structured questionnaire.”
McDougall JA, Malone KE, Daling JR, Cushing-Haugen KL, Porter PL, and Li CI. Long-term statin use and risk of ductal and lobular breast cancer among women 55 to 74 years of age. Cancer Epidemiol Biomarkers Prev, 2013 Sep; 22(9): 1529-1537.
Jean A. McDougall
Division of Public Health Sciences
Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N
M4-C308, Seattle, WA 98109 USA