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    Older people with high LDL levels live as long or longer as those with low LDL in 16 of 19 studies

    Posted by .(JavaScript must be enabled to view this email address)
    Monday, June 13, 2016 10:10 am Email this article

    In people over 60, those with the highest LDL cholesterol levels were at a lower risk of dying over some number of years than those with the lowest LDL levels in 16 of 19 studies according to a new review paper by Uffe Ravnskov, MD, PhD, author of The Cholesterol Myths, Dr. Malcolm Kendrick, author of The Great Cholesterol Con, and others.

    One-fourth with highest LDL levels 29-59% less likely to die over next 3-9 years

    In 12 of those studies, the one-fourth of people with the highest LDL levels were 29% to 59% less likely to have died over the next 3-9 years than the one-fourth of people with the lowest LDL levels.

    A reanalysis of an old study found that a 30 mg/dL decrease in total cholesterol levels in people 65 and older was associated with a 35% GREATER risk of death.

    Conclusion: Elderly people with High LDL live as long or longer than those with low LDL

    “High [LDL cholesterol] is inversely associated with mortality in most people over 60 years,” the authors of the paper concluded.

    “This finding is inconsistent with the cholesterol hypothesis (ie, that cholesterol, particularly [LDL cholesterol] is inherently atherogenic).

    “Since elderly people with high [LDL cholesterol] live as long or longer than those with low [LDL cholesterol], our analysis provides reason to question the validity of the cholesterol hypothesis.

    “Moreover, our study provides the rationale for a re-evaluation of guidelines recommending pharmacological reduction of [LDL cholesterol] in the elderly as a component of cardiovascular disease prevention strategies.”

    Older people with high LDL lived as long or longer than those with low LDL

        “[E]lderly people with high LDL-[cholesterol] live as long or longer than those with low LDL-[cholesterol].”
    — Abstract

    People with the highest LDL were 36% less like to die over the next 4 years

        “It is worth considering that some of the participants with high LDL-[cholesterol]  may have started statin treatment during the observation period.
        “Such treatment may have increased the lifespan for the group with high LDL-[cholesterol] .
        “However, any beneficial effects of statins on mortality would have been minimal because most statin trials have had little effect on CVD and all-cause mortality, with a maximum reduction of mortality of two percentage points.
        “It is therefore relevant that the 4-year mortality among those with the highest LDL-[cholesterol] in the included cohorts was up to 36% lower than among those with the lowest LDL-[cholesterol].”
        — page 3, col. 2

    Recent study found a 30 mg/dL drop in total cholesterol was associated with a 35% greater risk of death

        “In a recent study, the authors reported that among participants who were older than 65 at baseline, a 30 mg/dL decrease in serum cholesterol was associated with a [35%] higher risk of death.”
        — Page 5, col. 1

    In almost 80% of people in these studies, higher LDL levels were associated with a lower risk of death

        “Our literature review has revealed either a lack of an association or an inverse association between LDL-[cholesterol] and mortality among people older than 60 years.
        “In almost 80% of the total number of individuals, LDL-[cholesterol] was inversely associated with all-cause mortality and with statistical significance.”
        — Page 6, col. 1

    9 studies found higher total cholesterol was associated with a lower risk of cancer over 10-30 years

        “Nine cohort studies including more than 140 000 individuals followed for 10–30 years have found an inverse association between cancer and [total cholesterol] measured at the start of the study, even after excluding deaths that occurred during the first 4 years.”
        — Page 6, col. 2

    Several studies have found that people with cancer were more likely to be on a cholesterol-lowering treatment than people who did not have cancer

        “Furthermore, cholesterol-lowering experiments on rodents have resulted in cancer, and in several case-control studies of patients with cancer and controls matched for age and sex, significantly more patients with cancer have been on cholesterol-lowering treatment.”
        — Page 6, col. 2

    People who have a heart attack have LOWER LDL levels than normal, not higher

        “That high LDL-[cholesterol] may be protective is in accordance with the finding that LDL-[cholesterol] is lower than normal in patients with acute myocardial infarction.
        “This has been documented repeatedly without a reasonable explanation.
        “In one of the studies, the authors concluded that LDL-[cholesterol] evidently should be lowered even more, but at a follow-up 3 years later mortality was twice as high among those whose LDL-[cholesterol] had been lowered the most compared with those whose cholesterol was unchanged or lowered only a little.
        “If high LDL-C were the cause, the effect should have been the opposite.”
        — Page 6, col. 2

    LDL helps to protect us from infections by inactivating bacteria and viruses

        “LDL binds to and inactivates a broad range of microorganisms and their toxic products.”
        — Page 6, col. 1

    Higher total cholesterol was associated with a lower risk of dying from respiratory and gastrointestinal diseases in 19 studies

        “In a meta-analysis of 19 cohort studies, for instance, performed by the National Heart, Lung and Blood Institute and including 68 406 deaths, [total cholesterol] was inversely associated with mortality from respiratory and gastrointestinal diseases, most of which are of an infectious origin.
        “It is unlikely that these diseases caused the low [total cholesterol]  because the associations remained after the exclusion of deaths occurring during the first 5 years.”
        — Page 6, col. 1

    High LDL levels were NOT associated with an increase in death from heart attack, stroke or all-cause mortality

        “Our review has shown either a lack of an association or an inverse association between LDL-[cholesterol] and both all-cause and [cardiovascular] mortality.’
        — Page 6, col. 2

    This analysis suggests that the cholesterol hypothesis of cardiovascular disease is wrong

        “Our review has shown either a lack of an association or an inverse association between LDL-[cholesterol] and both all-cause and [cardiovascular] mortality.
        “The cholesterol hypothesis seems to be in conflict with most of Bradford Hill’s criteria for causation, because of its lack of consistency, biological gradient and coherence.”

    The guidelines for heart disease must be re-evaluated

        “Our review provides the basis for more research about the cause of atherosclerosis and [cardiovascular disease] and also for a re-evaluation of the guidelines for cardiovascular prevention, in particular because the benefits from statin treatment have been exaggerated.”
        — Page 6, col. 2


    Ravnskov U, Diamond DM, Hama R, Hamazaki T, Hammarskjöld B, Hynes N, Kendrick M, Langsjoen PH, Malhotra A, Mascitelli L, McCully KS, Ogushi Y, Okuyama H, Rosch PJ, Schersten T, Sultan S, and Sundberg R. Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review. BMJ Open, 2016; 6(6): e010401.

    Author’s Contact Info

    Uffe Ravnskov, MD, PhD
    .(JavaScript must be enabled to view this email address)



    Some articles about statins

    ‘This review strongly suggests that statins are not effective’ says two cardiologists

    Present claims about safe and efficacy of statins are not evidence-based says two cardiologists

    Crestor (rosuvastatin) is NOT effective at preventing heart attack or death says two cardiologists

    No statin is more effective than any other says two cardiologists; (all are equally ineffective!)

    Intense cholesterol-lowering with statins is not better than less-intense says two cardiologists

    Statins appear ineffective in chronic heart failure and chronic kidney failure says two cardiologist

    Statins do not appear to protect diabetics says two cardiologists

    It is worrisome that it took 30 years to realize statins increase diabetes says two cardiologists

    Statins are likely a major contributing factor to the one million heart failures in US each year

    Statin-induced impairment in heart muscle function appears to be permanent

    Statins provide no beneficial effect on coronary heart disease in trials since 2004-2005

    Statins can cause congestive heart failure

    Statins can cause coronary artery calcification by inhibiting synthesis of vitamin K2

    Statins are NOT effective, but can CAUSE heart disease, heart failure and diabetes

    Statins increase survival by only 3-4 days!

    Statins associated with 4.4-fold greater risk of memory loss

    5-fold increased risk of dying from CHD when cholesterol levels fall 40 mg/dL (1 mmol/L) Dr Kendrick

    ALLHAT study found NO benefit to taking statins notes Dr. Malcolm Kendrick

    Prolonged use of statins associated with a 18% increased risk of lung cancer

    Prolonged use of statins associated with a 23% increased risk of colorectal cancer

    Prolonged use of statins associated with a 29% increased risk of bladder cancer

    Statins increase kidney failure, 23 extra patients per 10,000 statin users

    Statins increase cataracts, 307 extra patients per 10,000 statin users

    Statins increase liver dysfunction, 74 extra patients per 10,000 statin users

    Statins increases muscle fatigabilty by 30%

    11.3% of patients taking high dose statins experienced rhabdomyolysis

    Statins increase erectile dysfunction 10-fold in young men

    Statins can induce insulin resistance

    Statins increase the risk of non-melanoma skin cancers 1.6-fold

    Long-term statin use is associated with a 23% increased risk of colorectal cancer

    Long-term statin use is associated with a 29% increased risk of colorectal cancer

    Long-term statin use is associated with a 18% increased risk of lung cancer

    High cholesterol levels are protective in the elderly

    High cholesterol levels are protective in heart failure patients

    Low cholesterol levels are associated with higher incidence of bleeding in the brain

    Low cholesterol levels are associated with higher incidence of depression

    Low cholesterol levels are associated with higher incidence of cancer

    Higher cholesterol levels are associated with an decreased risk of Parkinson’s

    Statins increase life expectancy by only 2 weeks in those with a heart attack, Dr. Malcolm Kendrick

    Statins do NOT increase life expectancy by even one day in the general population, Malcolm Kendrick

    Low cholesterol levels INCREASE the risk of cancer notes Uffe Ravnskov, MD, PhD

    Those who have LOW cholesterol levels are likely to die YOUNGER notes Dr. Malcolm Kendrick

    HIGHER cholesterol as associated with LONGER life, fewer infections and cancer, Uffe Ravnskov MD PhD

    8 of 9 panel members who wrote the cholesterol guidelines were paid by the drug companies

    Statin side effects, 51-yr-old women: depression, amnesia, incredible fatigue, chest pain, insomnia

    Statin side effects: ‘Life was pretty unbearable’, constant pain, fatigue, did not feel well, Tony W

    LDL cholesterol binds to and inactivates bacteria and viruses, Uffe Ravnskov, MD, PhD

    Statins increase the risk of developing Type 2 diabetes by 25-30% notes Dr. Malcolm Kendrick

    Statin-induced side effects: depression, fatigue, memory loss, arrhythmia, Katherine Faraday, MD

    Statins are destroying the lives of countless people around the world, Malcolm Kendrick, MD

    Cholesterol-lowering May Shorten Your Life by Uffe Ravnskov, MD PhD

    Statins For Children - This Is Madness by Dr. Malcolm Kendrick, author of The Great Cholesterol Con

    Thank God He Didn’t Die Of Heart Disease Doctor Dr. Malcolm Kendrick

    While statin use increased, so did heart disease, strokes and diabetes (1999-2005)

    Statins treat lab values, but not much else says Michael Eades, MD

    Niacin reduced heart attacks by 67% versus Zetia (ezetimibe) in statin users (1 vs 3 heart attacks)

    Niacin reduced cardiovascular deaths 80% versus Zetia (ezetimibe) in statin users (1 vs 5 deaths)

    Red yeast rice extract reduces deaths by 32%

    Statins INCREASE the risk of dying by 1% over 10 years

    Two cholesterol drugs, Zocor plus Zetia, increased the risk of death by 4%, cancer 48% - Part 1

    Two cholesterol drugs, Zocor plus Zetia, increased the risk of cancer by 48% - Part 2

    Zocor (a statin) plus Zetia increased cancer 48%, fatal cancers 67%

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