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Breast cancer 12 times more common in women given a statin in the CARE trial
Thursday, July 21, 2016 9:01 am Email this article
Among women in the 1998 CARE trial in which people were given pravastatin to reduce cholesterol levels, there were 12 cases of breast cancer in women given the statin versus only one women who was given a placebo.
Total number of cancer cases was nearly twice as great in women given a statin as women given a placebo (23 cases versus 12 cases).
Lots of experimental evidence shows that lower cholesterol levels are associated with a higher risk of cancer, and higher cholesterol levels are associated with a lower risk of cancer.
Lewis SJ, Sacks FM, Mitchell JS, East C, Glasser S, Kell S, Letterer R, Limacher M, Moye LA, Rouleau JL, Pfeffer MA, and Braunwald E. Effect of pravastatin on cardiovascular events in women after myocardial infarction: the cholesterol and recurrent events (CARE) trial. J Am Coll Cardiol, 1998 Jul; 32(1): 140-146.
The paper is available here.
Author’s Contact Info
Frank Sacks, MD
Professor of Cardiovascular Disease Prevention
Department of Nutrition
Department of Genetics and Complex Diseases
Building 1, Room 203
665 Huntington Avenue
Boston, Massachusetts 02115
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