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Low cholesterol levels associated with 2.3 times greater risk of Parkinson’s disease
Tuesday, May 08, 2018 6:59 am Email this article
The one-third of people with the highest cholesterol levels were 57% less likely to get Parkinson’s during a 20-year follow-up compared to the one-third of people with the lowest cholesterol levels according to a recent study.
The one-third of people with the middle cholesterol levels were 44% less likely to get Parkinson’s compared to the one-third of people with the lowest cholesterol levels.
The say this the other way, the one-third of people with the lowest cholesterol levels were 2.3 times more likely to get Parkinson’s than the one-third of people with the highest cholesterol levels, and they were 1.8 times more likely to get Parkinson’s compared to the one-third of people with the middle cholesterol levels.
“Our study suggests that lowering cholesterol unnecessarily actually may harm the brain,” Xuemei Huang, MD, PhD lead author of the study was quoted as saying.
“Statin use may be associated with a higher Parkinson’s risk, whereas higher total cholesterol may be associated with lower risk,” the authors of the paper concluded.
Cholesterol levels of each group not specified
Unfortunately the study does not give the cutoffs for each group.
Just taking a wild guess, perhaps the one-third with the lowest cholesterol levels had levels of 170 or 180 mg/dl or less, the middle one-third had levels of 170-180 to 230-240 mg/dl, and the upper one-third had levels of 230-240 mg/dl or more.
Subjects: 15,291 people
Between 1987 and 1989, the study recruited 15,792 participants aged 45–64 years.
They were followed up in 2006-2008.
15,291 participants were included in the current analysis.
Huang X, Alonso A, Guo X, Umbach DM, Lichtenstein ML, Ballantyne CM, Mailman RB, Mosley TH, and Chen H. Statins, plasma cholesterol, and risk of Parkinson’s disease: a prospective study. Mov Disord, 2015 Apr; 30(4): 552-559.
Author’s Contact Info
Xuemei Huang, MD, PhD
Professor and Vice Chair for Research, Neurology
Penn State College of Medicine
Penn State Hershey Neurology
30 Hope Drive, Building B, Suite 1300
Hershey, Pennsylvania USA
Tel: 800-243-1455 / 717-531-3828 / (717) 531-3828
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