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Statins increase risk of Type 2 diabetes 46% due to decreased insulin secretion and sensitivity
Friday, January 13, 2017 12:58 pm Email this article
“Statin treatment increased the risk of type 2 diabetes by 46%, attributable to decreases in insulin sensitivity and insulin secretion,” concludes a 2015 study that followed 8,749 non-diabetic participants, 45– to 73-years-old, for 5.9 years.
Insulin sensitivity and insulin secretion decreased
Insulin sensitivity decreased 24%, insulin secretion decreased 12%
Insulin sensitivity was decreased by 24% and insulin secretion by 12% in people on statins compared with people who were not on statins.
Risk was dose-dependent
The risk was dose-dependent for simvastatin (Zocor) and atorvastatin (Lipitor).
Subjects: 8,749 non-diabetic participants, 45–73 years-old, followed up for 5.9 years
The study involved 8,749 non-diabetic participants, aged 45–73 years, who were followed up for 5.9 years.
Cederberg H, Stancakova A, Yaluri N, Modi S, Kuusisto J, and Laakso M. Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort. Diabetologia, 2015 May; 58(5): 1109-1117.
Author’s Contact Info
Institute of Clinical Medicine
University of Eastern Finland
Kuopio University Hospital
P.O. Box 1627
70211 Kuopio, Finland
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