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Men with high HDL levels above 90 mg/dl were 68% more likely to die over next 4.9 years
Friday, March 10, 2017 12:23 pm Email this article
Men with high HDL cholesterol levels of greater than 90 mg/dl were 68% more likely to die (from any cause) during an average follow-up of 4.9 years than men with HDL levels of 51-60 mg/dl according to a 2016 study from Canada.
(12.1 per 1,000 men with HDL levels greater than 90 mg/dl died versus 7.2 men with HDL levels of 51-60 mg/dl. 12.1 divided by 7.2 equals 1.68.)
The study found that HDL levels that were either too high (>90 mg/dl) or too low (≤30 mg/dl) were associated with an increased risk of death when compared to men with more moderate HDL levels (41-80 mg/dl).
HDL is not a cardiovascular-speciﬁc risk factor
HDL is not a target for intervention
Because people with high HDL levels were more likely to die from cancer and non-cardiovascular causes, the authors of the study concluded that:
“These ﬁndings suggested that HDL [cholesterol] level is unlikely to represent a cardiovascular-speciﬁc risk factor or a target for intervention given similarities in its associations with non cardiovascular outcomes,” the authors of the study concluded.
Subjects: 631,762 people
The study followed 631,762 people from the CANHEART (Cardiovascular Health in Ambulatory Care Research Team) dataset, which was created by linking together 17 different individual-level data sources.
On average, people were 57-years-old and had an HDL level of 55 mg/dl.
Ko DT, Alter DA, Guo H, Koh M, Lau G, Austin PC, Booth GL, Hogg W, Jackevicius CA, Lee DS, Wijeysundera HC, Wilkins JT, and Tu JV. High-Density Lipoprotein Cholesterol and Cause-Specific Mortality in Individuals Without Previous Cardiovascular Conditions: The CANHEART Study. J Am Coll Cardiol, 2016 Nov 08; 68(19): 2073-2083.
Author’s Contact Info
Dennis. T. Ko
nstitute for Clinical Evaluative Sciences
G106-2075 Bayview Avenue
Toronto, Ontario M4N 3M5, Canada
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