Proton pump inhibitors (PPI’s) increase risk of Alzheimer’s by 44%

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Tuesday, May 22, 2018 7:37 am Email this article

Patients 75 years and older taking a proton pump inhibitor (PPI) were 38% more likely to have any type of dementia and 44% more likely to have Alzheimer’s than non-users according to a study from Germany.

 

List of PPI’s

Available proton pump inhibitors include:

• omeprazole (Prilosec, Prilosec OTC)
• aspirin and omeprazole (Yosprala)
• lansoprazole (Prevacid, Prevacid IV, Prevacid 24-Hour)
• dexlansoprazole (Dexilent, Dexilent Solutab)
• rabeprazole (Aciphex, Aciphex Sprinkle)
• pantoprazole (Protonix)
• esomeprazole (Nexium, Nexium IV, Nexium 24 HR)
• esomeprazole magnesium/naproxen (Vimovo)
• omeprazole/sodium bicarbonate (Zegerid, Zegerid OTC)

Reference

Haenisch B, von Holt K, Wiese B, Prokein J, Lange C, Ernst A, Brettschneider C, Konig HH, Werle J, Weyerer S, Luppa M, Riedel-Heller SG, Fuchs A, Pentzek M, Weeg D, Bickel H, Broich K, Jessen F, Maier W, and Scherer M. Risk of dementia in elderly patients with the use of proton pump inhibitors. Eur Arch Psychiatry Clin Neurosci, 2015 Aug; 265(5): 419-428.

Author’s Contact Info

Britta Haenisch
German Center for Neurodegenerative Diseases (DZNE)
c/o Federal Institute for Drugs and Medical Devices (BfArM)
Kurt-Georg-Kiesinger-Allee 3
53175, Bonn, Germany
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Articles on the same subject can be found here:

• Alzhemier's Disease

• Dementia (see Alzheimer's also)

• Proton pump inhibitors