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Proton pump inhibitors (PPI’s) increase risk of major depression as much as 2-fold
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Tuesday, May 22, 2018 8:16 am Email this article
Proton pump inhibitors (PPI’s) increase the risk of major depression according to a study from Taiwan.
People taking 31-120 doses per year were 10% more likely (1.1 times more likely) to have major depression than non-users.
(This difference did not quite reach statistical significance, but was very close—close enough for me.)
People taking 121-365 doses per year were 61% more likely (1.6 times more likely) to have major depression than non-users.
People taking more than 365 doses per year were 108% more likely (2.1 times more likely) to have major depression than non-users.
The risk of subsequent major depression after starting various PPI’s is shown below.
Risk of Subsequent Depression
Risk of Subsequent Major Depression After Starting a PPI
The risk of subsequent major depression after starting a PPI increased as follows:
- Pantoprazole: 49% increased risk of subsequent major depression; (Protonix)
- Rabeprazole: 31% increased risk of subsequent major depression; (AcipHex)
- Lansoprazole: 26% increased risk of subsequent major depression; (Prevacid, Heartburn Treatment 24 Hour, Prevacid SoluTab, and Prevacid 24Hr)
- Esomeprazole: 13% increased risk of subsequent major depression; (Nexium, Nexium IV, Nexium 24HR, and Nexium Packet)
- Omeprazole: 11% increased risk of subsequent major depression; (Zegerid, Prilosec OTC, Zegerid OTC, and OmePPi)
Subjects
Subjects: 2,366 patients who took PPI’s and developed subsequent major depressive disorder and 9,464 comparison subjects without depression
The study included “2,366 patients who were exposed to PPI’s and developed subsequent major depressive disorder and 9,464 comparison subjects without major depressive disorder, matched for age, sex, enrollment time, end point time, and follow-up period”.
Reference
Huang WS, Bai YM, Hsu JW, Huang KL, Tsai CF, Su TP, Li CT, Lin WC, Tsai SJ, Pan TL, Chen TJ, and Chen MH. Use of Proton Pump Inhibitors and Risk of Major Depressive Disorder: A Nationwide Population-Based Study. Psychother Psychosom, 2018; 87(1): 62-64.
Author’s Contact Info
Mu-Hong Chen, MD
Depart of Psychiatry
Taipei Ventrains General Hostpical
No. 201, Shih-Pai Road, Sec 2
Taipei 11217 Taiwan
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