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  • Leptin levels fall 50 percent during weight loss


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    Tuesday, April 27, 2004 12:12 am Email this article
    LEPTIN LEVELS FELL 53 percent in a group of obese people who lost 10 percent of their body weight according to one study.

    After one month of weight maintenance leptin levels rose to approximately 70 percent of the pre-weight loss levels.

    LEPTIN 4 TIMES HIGHER IN OBESE

    Leptin levels before weight loss were on average four times higher in obese subjects than they were in normal-weight subjects (31.3 ng/ml vs 7.5 ng/ml, respectively), however, there was great variation among each group.

    LEPTIN LEVELS VARY 50-FOLD

    Levels varied 50-fold in obese subjects; the highest level being almost 100 ng/ml while the lowest was 1.7 ng/ml.

    SOME NORMAL WEIGHT PEOPLE HAVE NO LEPTIN

    Seven percent of normal-weight subjects had no detectable levels of leptin at all.

    Levels strongly correlated with body fat.

    LEPTIN HIGHER IN WOMEN BECAUSE OF MORE BODY FAT

    Women’s leptin levels were higher men’s. However, leptin levels were the same when comparing men and women with the same amount of body fat.

    MEALS DO NOT AFFECT LEPTIN LEVELS

    Levels did not change before or after meals.

    RESULTS SUGGEST THREE THINGS

    The results of this study suggest three things:

    1. many obese people seem to be insensitive to leptin
    2. leptin injections may help some people lose weight (those with low leptin levels)
    3. leptin injections may help maintain weight loss (when leptin levels naturally fall).
    4. Leptin is the hormone produced in fat cells by the ob gene. Leptin injections given to leptin-deficient ob/ob obese mice have been shown to decrease appetite, increase metabolism and cause dramatic weight loss. REFERENCE Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF. Serum immunoreactive-leptin concentrations in normal weight and obese humans. The New England Journal of Medicine, 334(5):292-5, Feb 1, 1995.

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