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High-intensity statin therapy increases risk of acute kidney injury in women by 29%
Friday, April 05, 2019 10:55 am Email this article
High-intensity statin therapy was found to increase the risk of hospitalization for acute kidney injury in women by 29% compared to non-users during a median follow-up of 4.6 years according to a new study.
The study showed that the risk of hospitalization for acute kidney injury with high-intensity statin use was greater among women than men.
The authors of the study speculated that the reason for this “may be due to higher blood levels of statin at a given dose among women than in men, due to the generally lower body size of women.”
High-intensity statin therapy was defined as:
- Rosuvastatin 10 mg or more
- Atorvastatin 20 mg or more
- Simvastatin 80 mg or more
Tonelli M, Lloyd AM, Bello AK, James MT, Klarenbach SW, McAlister FA, Manns BJ, Tsuyuki RT, and Hemmelgarn BR. Statin use and the risk of acute kidney injury in older adults. BMC Nephrol, 2019 Mar 25; 20(1): 103.
The paper is posted here:
Author’s Contact Info
Department of Medicine
University of Calgary
7th Floor, TRW Building
3280 Hospital Drive NW
Calgary, Alberta T2N 4Z6, Canada
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