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Potassium citrate plus potassium bicarbonate dissolve uric acid kidney stones in 5 of 8 people
Tuesday, June 18, 2019 8:59 am Email this article
1500 mg of potassium per day in the form of potassium citrate (40 mEq) plus 800 mg of potassium per day in the form of potassium bicarbonate (20 mEq) dissolved uric acid kidney stones in 5 of 8 people according to a study from researchers in the Urology Unit at Manzoni Hospital in Lecco, Italy.
In 3 of the 8 people, their kidney stones dissolved within 1.5 months; in the 4th person, their kidney stone dissolved within 4 months of continued treatment; and in the 5th person, their kidney stone dissolved within 6 months of continued treatment.
“Uric acid stone disease is dependent on three pathogenetic factors: acid urine pH, low urine volume, and hyperuricosuria [ excess amounts of uric acid in the urine ],” the authors of the paper note.
“However, the most important factor for uric acid stone formation is persistently acidic urine that represents a prerequisite for uric acid stone formation and growth.”
“Urinary alkalization with alkali administration [ of potassium citrate and potassium bicarbonate ] has been advocated for dissolution of stones on the basis of established clinical experience.”
“Urinary alkalization with potassium citrate/bicarbonate is a well tolerated and highly effective treatment, resulting in dissolution of nonobstructing uric acid stones.”
There are 3 types of kidney stones
90% of kidney stones are calcium kidney stones, and 10% are uric acid stones or other types of stones as noted below.
“Over 90 percent of all stones are composed of calcium, either calcium oxalate or [ calcium ] phosphate. The remaining 10 percent include uric acid, cysteine [ he meant to say cystine ] and matrix stones [ which are rare ],” according to Fernando Cabrera, MD from The Cleveland Clinic as posted here.
Potassium citrate (and probably potassium bicarbonate) reduces either calcium stones or uric acid stones, and so they may also help to dissolve calcium stones as well
Potassium citrate reduces formation of either calcium stones or uric acid stones—I assume potassium bicarbonate would work as well because potassium bicarbonate lowers urinary excretion of calcium as does potassium citrate—according to Fredric Coe, MD of the University of Chicago as noted here.
I [Larry Hobbs] assume that potassium citrate and potassium bicarbonate might also dissolve calcium stones as well as uric acid stones.
Trinchieri A, Esposito N, and Castelnuovo C. Dissolution of radiolucent renal stones by oral alkalinization with potassium citrate/potassium bicarbonate. Arch Ital Urol Androl, 2009 Sep; 81(3): 188-191.
Author’s Contact Info
Urology Unit, Manzoni Hospital
Via dell’Eremo 9/11
23900, Lecco, Italy
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