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  • Tenuate (diethylpropion): Similar weight loss, but greater compliance during six week study


    Posted by .(JavaScript must be enabled to view this email address)
    Thursday, May 06, 2004 4:03 pm Email this article
    More patients stuck with a prescribed diet for six weeks and lost weight when they were given 75 mg of sustained-release diethylpropion than those who were given a placebo (78 percent versus 50 percent, respectively). However, weight loss was similar among those who lost weight in both group (6.5 pounds versus 6.4 pounds).

    Side effects were twice as common in those taking diethylpropion as placebo (37 percent versus 16 percent) and included nervousness, headache, nausea, constipation, dry mouth, insomnia, rash, bad taste, flush, palpitations.

    One patient taking the diethylpropion dropped out because of headache and dry mouth.

    There were no significant changes in blood pressure in any patient.

    REFERENCE

    Noble R. A controlled study of a weight reduction regimen. Curr Ther Res Clin Exp. 1971 Nov, 13(11):685-91.

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