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  • Tenuate (diethylpropion): 18 lbs weight loss in four months

    Posted by .(JavaScript must be enabled to view this email address)
    Thursday, May 06, 2004 4:13 pm Email this article
    Patients lost slightly more weight taking 75 mg of sustained-release diethylpropion daily for four months compared to those who took it intermittently one month at a time, either starting with the drug or with the placebo (18 pounds versus 16.4 pounds versus 12.4 pounds).

    Note that intermittent therapy was more effective when starting with the drug.

    Silverstone had expected just the opposite.

    Side effects were reported by more often by patients taking diethylpropion than taking placebo (30 percent versus 5 percent, respectively).

    Side effects included CNS stimulation (insomnia, irritability, tension) (15 percent of patients), dry mouth (6 percent), gastrointestinal (3 percent), headache (4 percent), depression (4 percent), cardiovascular symptoms (1 percent).

    Blood pressure rose at least 20 mmHg systolic or 10 mmHg diastolic in six patients.

    In two of these patients blood pressure fell after the first month.

    There was no indication of drug dependency, and substituting placebo for diethylpropion cause no psychological stress.

    The study involved 96 obese women who were instructed to eat a low-carbohydrate, reduced-calorie diet.


    Silverstone T. Intermittent treatment with anorectic drugs. Practitioner. 1974 Aug, 213(1274):245-52.

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