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  • Antipsychotic drug weight gain: 7% gain in one-third taking Zyprexa, one-fourth Seroquel


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    Monday, June 21, 2004 6:22 am Email this article
    The United States Federal Drug and Food Administration defines weight gain related to any given drug as an increase of 7 percent of bodyweight. Based on this definition, one study reported that a 7 percent weight gain was observed in 29 percent of patients treated with Zyprexa (olanzapine), 25 percent treated with Seroquel (quetiapine), 18 percent with Risperdal (risperidone), and 9.8 percent treated with Geodon (ziprasidone).

    REFERENCE

    Tandon R, Harrigan E, Zorn S. Ziprasidone: a novel antipsychotic with unique pharmacology and therapeutic potential. J Serotonin Res. 1997, 4:159???177 as referenced in Muller D, Muglia P, Fortune T, Kennedy J. Pharmacogenetics of antipsychotic-induced weight gain. Pharmacol Res. 2004 Apr, 49(4):309-29.

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