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    Women with Polycystic Ovarian Syndrome have greater appetite and less satiety

    Posted by .(JavaScript must be enabled to view this email address)
    Friday, July 09, 2004 12:48 pm Email this article
    Women with Polycystic Ovarian Syndrome (PCOS) seem to have problems with appetite regulation due to a dysregulation of ghrelin, a hormone involved in appetite according to a new study from Australia.

    Women with Polycystic Ovarian Syndrome reported greater hunger and less satiety after a meal.

    Changing the levels of protein and carbohydrates they ate from 15 percent protein and 55 percent carbohydrates to 30 percent protein and 40 percent carbohydrates had no effect on feelings of hunger or satiety.

    The reason for this effect on appetite and satiety seems to be due to a dysregulation of the hormone ghrelin which is involved in appetite.

    Fasting ghrelin levels were 70 percent higher in normal women than in women with Polycystic Ovarian Syndrome, and increases in fasting ghrelin were greater following weight loss in normal women than those with PCOS.

    Ghrelin levels also fell much more in normal women following a meal than in women with this syndrome—a fall in ghrelin levels of 144 pg/ml in normal women following a meal versus a fall of only 29 pg/ml in women with PCOS.

    Comment: This suggests to me that appetite suppressants are appropriate or necessary for women with this condition to help them to regulate appetite and prevent or reduce weight gain.


    Moran L, Noakes M, Clifton P, Wittert G, Tomlinson L, Galletly C, Luscombe N, Norman R. Ghrelin and measures of satiety are altered in polycystic ovary syndrome but not differentially affected by diet composition. J Clin Endocrinol Metab. 2004 Jul, 89(7):3337-44.


    L. Moran
    P.O. Box 10041 BC
    Adelaide, South Australia
    Australia 5000
    .(JavaScript must be enabled to view this email address)

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