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  • Ghrelin blocks the appetite-reducing effect of leptin

    Posted by .(JavaScript must be enabled to view this email address)
    Thursday, July 29, 2004 3:07 pm Email this article
    Ghrelin blocks the appetite-reducing effect of leptin according to a study performed on rats.

    An injection of leptin decreased food intake by 39 percent and fat mass by 41 percent, however, an injection of ghrelin blocked these effects.

    Ghrehlin is a hormone, produced primarily by the stomach, that increases food intake and is thought to play a role in the long-term regulation of body weight.

    I previously reviewed an paper which found that fructose increases ghrelin and decreases leptin. This suggests that, if leptin ever becomes a treatment for obesity, consuming large amounts of fructose could block the effects of the drug.


    Kim M, Namkoong C, Kim H, Jang P, Kim Pak YM, Katakami H, Park J, Lee K. Chronic central administration of ghrelin reverses the effects of leptin. Int J Obes Relat Metab Disord. 2004 Jul 27.

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