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Ovarian cancer: Being obese may increase the risk 1.5 to 2-fold
Monday, August 09, 2004 3:10 am Email this article
It isn't clear whether or not obesity increases the risk of ovarian cancer. Some studies have found the heaviest women have a 1.5 to 2 times greater risk, while other studies have not found any association between weight and risk of this cancer.
It is possible that obesity may increase the risk of some subtypes of ovarian cancer, for example, endometroid, but not other types according to the excellent review paper by Calle and Kaaks (2004). Studies have not examined this in detail, which may explain why the findings are inconsistent.
This information is according to an evaluation by The International Agency for Research on Cancer (IARC) Working Group on the Evaluation of Cancer-Preventive Strategies.
Their evaluation is a comprehensive evaluation of the available literature on weight and cancer that considered epidemiological, clinical and experimental data.
For an excellent review of the effect of overweight and obesity on the risk of cancers, see the review paper by Calle and Kaaks (2004).
International Agency for Reasearch on Cancer. IARC Handbooks of Cancer Prevention. Weight Control and Physical Activity (International Agency for Research on Cancer, Lyon, 2002) as referenced in Calle E, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer. 2004 Aug, 4(8):579-91.
Calle E, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer. 2004 Aug, 4(8):579-91.
AUTHOR’S CONTACT INFORMATION
American Cancer Society
1599 Clifton Road
Atlanta, Georgia 30306, USA
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