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    Acomplia (rimonabant) increases thermogenesis as well as initially reducing appetite

    Posted by .(JavaScript must be enabled to view this email address)
    Wednesday, June 08, 2005 9:00 am Email this article
    Acomplia (rimonabant) causes weight loss by both decreasing appetite and increasing thermogenesis according to a study in mice. Long-term weight loss with Acomplia may be largely to increased thermogenesis

    The long-term maintenance of weight loss may be largely due to the increased thermogenesis, in that a tolerance to the appetite-reducing effects was seen quickly in mice—after 4 days—but the animals maintained their lower body weight despite returning to eating a normal amount of food.

    Conclusion: Weight loss due to increased thermogenesis plus the initial reduction in appetite

    “It is concluded that [Acomplia (rimonabant)] has a direct effect on energy expenditure suggesting that the antiobesity effect of [Acomplia (rimonabant)] is due to activation of thermogenesis in addition to the initial hypophagia [reduced appetite],” the authors concluded.

    Comment: It would probably work better combined with appetite suppressant

    Comment: Since the appetite-reducing effect of Acomplia (rimonabant) does not seem to last, it seems that combining Acomplia (rimonabant) with an appetite suppressant would cause greater weight loss than Acomplia (rimonabant) alone.


    Liu Y, Connoley I, Wilson CA, Stock MJ. Effects of the cannabinoid cb1 receptor antagonist sr141716 on oxygen consumption and soleus muscle glucose uptake in lep(ob)/lep(ob) mice. Int J Obes Relat Metab Disord. 2005 Feb, 29(2):183-87.


    Y. Liu
    Department of Physiology
    Basic Medical Sciences
    St George’s Hospital Medical School
    Tooting, London SW17 0RE, UK
    .(JavaScript must be enabled to view this email address)


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    On Jun 08, 2005 at 11:19 am Randy Smith, MD wrote:

    . . . . .

    This drug looks promising - I can see a Phen-Com trend forming ahead.


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