Acomplia (rimonabant) increases thermogenesis as well as initially reducing appetite

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Wednesday, June 08, 2005 9:00 am Email this article
Acomplia (rimonabant) causes weight loss by both decreasing appetite and increasing thermogenesis according to a study in mice. Long-term weight loss with Acomplia may be largely to increased thermogenesis

The long-term maintenance of weight loss may be largely due to the increased thermogenesis, in that a tolerance to the appetite-reducing effects was seen quickly in mice—after 4 days—but the animals maintained their lower body weight despite returning to eating a normal amount of food.

Conclusion: Weight loss due to increased thermogenesis plus the initial reduction in appetite

“It is concluded that [Acomplia (rimonabant)] has a direct effect on energy expenditure suggesting that the antiobesity effect of [Acomplia (rimonabant)] is due to activation of thermogenesis in addition to the initial hypophagia [reduced appetite],” the authors concluded.

Comment: It would probably work better combined with appetite suppressant

Comment: Since the appetite-reducing effect of Acomplia (rimonabant) does not seem to last, it seems that combining Acomplia (rimonabant) with an appetite suppressant would cause greater weight loss than Acomplia (rimonabant) alone.

REFERENCE

Liu Y, Connoley I, Wilson CA, Stock MJ. Effects of the cannabinoid cb1 receptor antagonist sr141716 on oxygen consumption and soleus muscle glucose uptake in lep(ob)/lep(ob) mice. Int J Obes Relat Metab Disord. 2005 Feb, 29(2):183-87.

AUTHOR’S CONTACT INFORMATION

Y. Liu
Department of Physiology
Basic Medical Sciences
St George’s Hospital Medical School
Tooting, London SW17 0RE, UK
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• Acomplia (rimonabant)