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All-cause mortality 51% higher over one year when older patients take an SSRI
Saturday, December 31, 2016 10:20 am Email this article
All-cause mortality over one-year was 51% higher in people over 65 taking a serotonin reuptake inhibitor (SSRI) antidepressant compared to when patients were not taking an antidepressant according to a 2011 study from the U.K.
The absolute death rate was 10.61% over one year in those taking a tricyclic antidepressant compared to 7.04% for those not taking an antidepressant.
Subjects: 60,746 patients, 65- to 100-years-old
The study included 60,746 patients from 570 general practices in the United Kingdom diagnosed as having a new episode of depression between the ages of 65 and 100 years from 1 January 1996 to 31 December 2007 and followed up until 31 December 2008.
Coupland C, Dhiman P, Morriss R, Arthur A, Barton G, and Hippisley-Cox J. Antidepressant use and risk of adverse outcomes in older people: population based cohort study. BMJ, 2011 Aug 02; 343: d4551.
Author’s Contact Info
Division of Primary Care
School of Medicine
University of Nottingham
Nottingham NG7 2RD, UK
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