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    Aspirin lowers the risk of heart attack, stroke and cardiovascular death by 11%

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    Tuesday, January 22, 2019 5:07 pm Email this article

    Aspirin use lowers the risk of a cardiovascular event—heart attack, stroke and cardiovascular death—by 11% and increases the risk of a major bleed by 43% according to a new meta analysis in JAMA that analyzed 13 aspirin trials randomizing 164, 225 participants.

    The absolute risk reduction was 0.38%, and the number needed to treat to benefit one person was 265.

    The absolute risk increase was 0.47%, and the number needed to harm one person was 210.


    Zheng SL, and Roddick AJ. Association of Aspirin Use for Primary Prevention With Cardiovascular Events and Bleeding Events: A Systematic Review and Meta-analysis. JAMA, 2019 Jan 22; 321(3): 277-287.

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