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Heart disease: Low-carb diet better at reducing C-reactive protein
Tuesday, September 28, 2004 6:49 am Email this article
C-Reative protein is an independent risk factor for coronary heart disease. A low-carbohydrate diet is better than a conventional low-calorie diet at reducing high levels of C-reative protein according to a new study.
Both diets reduced LDL cholesterol and increased HDL cholesterol by a similar amount.
However, in patients with high risk levels of C-reactive protein—greater than 3 mg per deciliter—the low-carbohydrate diet was better than the conventional low-calorie diet at lowering these levels—2 mg greater decrease than the low-calorie diet.
Seshadri P, Iqbal N, Stern L, Williams M, Chicano K, Daily D, Mcgrory J, Gracely E, Rader D, Samaha F. A randomized study comparing the effects of a low-carbohydrate diet and a conventional diet on lipoprotein subfractions and c-reactive protein levels in patients with severe obesity. Am J Med. 2004 Sep 15, 117(6):398-405.
Department of Internal Medicine
Division of Endocrinology
University of Pennsylvania Health System
Philadelphia 19104, USA
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On Oct 02, 2004 at 12:12 pm robert skversky m.d. wrote:
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Is the lowering of crp levels in low carb diets related to more weight loss, more fat loss and thus less secretion of interluekin-6, or some other etiology?
On Oct 02, 2004 at 12:44 pm Larry Hobbs wrote:
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It is not related to weight loss.
The larger decrease in C-reative protein for those on a low-carb diet was independent of weight loss in this study.
I don't have a copy of the study so I don't know if there was a difference in fat loss or levels of IL-6.
The results of another study suggests to me that it may be the result of a lower glycemic load. (Brand-Miller, 2004)
The study found that in post-menopausal women, low glycemic index diets were associated with lower levels of C-reactive protein.
The study also found that people with the highest blood sugar levels following a glucose tolerance test were 1.8 to 3 times more likely to die.
They also noted that a study which gave the drug Acarbose to slow the absorption of carbohydrates reduced the risk of cardiovascular events and hypertension by about 50 percent.
Brand-Miller JC. Glycemic index in relation to coronary disease. Asia Pac J Clin Nutr. 2004, 13(Suppl):S3.
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